Table 3.
One-way Sensitivity Analyses Comparing Propofol and Midazolam
| Average Difference in Ventilation Duration, Days | ||||||
|---|---|---|---|---|---|---|
| Propofol | 4 | 5 | 6 | 6 | 6 | |
| Midazolam | 6 | 6 | 6 | 5 | 4 | |
| ICU Costs | ||||||
| Propofol | 27,044 | 32,595 | 38,147 | 37,792 | 37,437 | |
| Midazolam | 37,437 | 37,729 | 38,147 | 32,595 | 27,044 | |
| Hospital Ward Costs | ||||||
| Propofol | 6,209 | 7,626 | 9,042 | 8,952 | 8,861 | |
| Midazolam | 8,861 | 8,952 | 9,042 | 7,626 | 6,209 | |
| Sedative Costs | ||||||
| Propofol | 383 | 470 | 557 | 555 | 553 | |
| Midazolam | 227 | 232 | 238 | 204 | 169 | |
| Total Costs | ||||||
| Propofol | 33,636 | 40,690 | 47,745 | 47,299 | 46,851 | |
| Midazolam | 46,525 | 46,976 | 47,426 | 40,423 | 33,421 | |
| Incremental costs | −12,889 | −6,286 | 319 | 6,876 | 13,430 | |
| MVFDs | ||||||
| Propofol | 16.684 | 16.305 | 15.926 | 15.951 | 15.975 | |
| Midazolam | 15.975 | 15.951 | 15.926 | 16.305 | 16.684 | |
| Incremental effects | 0.709 | 0.354 | 0 | −0.354 | −0.709 | |
| ICERs | propofol | propofol | midazolam | midazolam | Midazolam | |
| dominates | dominates | less costly | dominates | dominates | ||
ICU = intensive care unit, MVFD = mechanical ventilator-free days, ICER = incremental cost-effectiveness ratio.
*
Assumes baseline average of 6 days of mechanical ventilation.