Skip to main content
. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Curr Opin Infect Dis. 2009 Jun;22(3):235–243. doi: 10.1097/QCO.0b013e32832a5963

Figure 1. Proteomic profiling of amniotic fluid and risk for preterm birth.

Figure 1

Panel A: Representative SELDI-TOF mass spectrometry profiles of the amniotic fluid based on the “severity” of inflammation (MR=0 “no” inflammation; MR=2 “minimal” inflammation; MR=3-4 “severe” inflammation). CHCA and SPA denote the energy absorbing molecules α-cyano-4-hydroxycinnamic acid or sinnapinic acid, respectively. The CHCA chip allows for the identification of defensins 2 and 1. The SPA chip allows for identification of the peaks corresponding to S100A12 (calgranulin C) and S100A8 (calgranulin A). The x axis of the tracings represents the molecular mass in Daltons; the y axis represents the relative peak intensity. Panel B: Cumulative probability of pregnancy maintenance for the 169 patients illustrating the duration from amniocentesis-to-delivery in women with MR (Mass Restricted) scores of 0 (zero), MR scores of 1-2, and MR scores 3-4. Originally published in Buhimschi et al. PLoS Med. 2007 Jan 16; 4(1):e18 (Reference 32). Republication by authors permitted under Creative Commons Attribution License.