Table 2. Computational model of the DNA replication checkpoint.

1.	$\begin{array}{ll}\frac{\text{d}[\text{MPF}]}{\text{d}t}=& -(k_{\text{MP}\_\text{Y}}[\text{Myt}1]+k_{\text{MP}\_\text{W}}[\text{Wee}1\text{P}])[\text{MPF}]+(k_{\text{M}}+k_{\text{M}\_\text{D}}[\text{Cdc25P}]\text{)}[\text{preMPF}]\\ & +k_{\text{MSYN}}-k_{\text{MDEG}}[\text{MPF}]\end{array}$
2.	$\begin{array}{ll}\frac{\text{d}[\text{preMPF}]}{\text{d}t}=& (k_{\text{MP}\_\text{Y}}[\text{Myt}1]+k_{\text{MP}\_\text{W}}[\text{Wee}1\text{P}])[\text{MPF}]-(k_{\text{M}}+k_{\text{M}\_\text{D}}[\text{Cdc}25\text{P}])[\text{preMPF}]\\ & +k_{\text{MSYN}}-k_{\text{MDEG}}[\text{preMPF}]\end{array}$
3.	$\begin{array}{ll}\frac{\text{d}[\text{Cdc}25]}{\text{d}t}=& k_{\text{D}}[\text{Cdc}25\text{P}]-(k_{\text{DP}}+k_{\text{DP}\_\text{M}}[\text{MPF}])[\text{Cdc}25]-(k_{\text{DS}}+k_{\text{DS}\_\text{C}}[\text{Chk}1])[\text{Cdc}25]\\ & +k_{\text{D}\_\text{S}}[\text{Cdc}25\text{S}]\end{array}$
4.	$\frac{\text{d}[\text{Cdc}25\text{P}]}{\text{d}t}=-k_{\text{D}}[\text{Cdc}25\text{P}]+(k_{\text{DP}}+k_{\text{DP}\_\text{M}}[\text{MPF}])[\text{Cdc}25]$
5.	$\frac{\text{d}[\text{Myt1}]}{\text{d}t}=-k_{\text{YP}\_\text{M}}[\text{MPF}][\text{Myt}1]+k_{\text{Y}}[\text{Myt}1\text{P}]$
6.	$\frac{\text{d}[\text{Wee1}]}{\text{d}t}=-(k_{\text{WP}}+k_{\text{WP}\_\text{C}}[\text{Chk1}]\text{)}[\text{Wee1}]+k_{\text{W}}[\text{Wee}1\text{P}]$
7.	$\frac{\text{d}[\text{Lamin}]}{\text{d}t}=-k_{\text{LP}\_\text{M}}[\text{MPF}][\text{Lamin}]$
8.	YT = [Myt1]+[Myt1P] = constant
9.	WT = [Wee1] + [Wee1P] = constant
10.	DT = [Cdc25] + [Cdc25P] + [Cdc25S] = constant