Table 4. Sources of data used for parameter estimation in the model.
# | Data type | Source | Fig # here | Parameter(s) estimated |
---|---|---|---|---|
1a | Cyclin thresholds | J. Moore (unpublished) | 3 | M0, MY, MD |
1b | MPF time lags | Sha et al 2003, Fig. 6D | 3 | kM_DDT |
2 | Cdc25 phos'n and dephos'n | Kumagai & Dunphy 1992 Fig 10 | 4 | kD, kDP, kDP_M |
3 | MPF phos'n and dephos'n | Kumagai & Dunphy 1995 Figs 3, 4 | 5 | kM_DDT, kM, kMP_YYT |
4a | NEB Time series: Wee1-depletion | Lee et al 2001, Fig 5 | 6 | KLP_M, KDS_S, KMSYN, μNEB, σNEB |
4b | NEB Time series: Mock-depletion | Lee et al 2001, Fig 5 | 6 | kMP_WWT, kW |
5 | NEB Time series: Cdc25-depletion and add-back | Kumagai et al 1998, Fig 6 | 7 | Test 1 |
6 | MPF kinase assay | Sha et al 2003 Fig 6 | 8 | Test 2 |