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. Author manuscript; available in PMC: 2009 Oct 19.
Published in final edited form as: Am J Trop Med Hyg. 2009 Apr;80(4):528–535.

TABLE 2.

Pharmacokinetics of pafuramidine and active metabolite DB75 after a 100-mg single oral dose*

Median values for 14 treated persons
(interquartile range)
Parameter Pafuramidine DB75
Cmax (ng/mL) 15.9 (7.0–33.6) 3.6 (2.6–4.6)
Elimination half-life (hours) 17.2 (10.8–24.0) 30.9 (20.2–36.2)
AUC0–144hr (ng·hours/mL) 292 (102–529) 112 (85.3–144)
*

Cmax = maximal plasma concentration; AUC = area under the concentration-time curve.