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. Author manuscript; available in PMC: 2010 Oct 15.

Published in final edited form as: Clin Cancer Res. 2009 Oct 13;15(20):6421–6429. doi: 10.1158/1078-0432.CCR-09-0945

Fig. 2 — Nude mice implanted with MDA-MB-435-GFP show correlation between tumor growth delay and GFP radiance. Nude mice (n=5 per group) were injected with MDA-MB-435-GFP tumor cells and were given vehicle control or 40 mg/kg of sunitinib once daily for five days. A, Tumor volumes were measured by caliper throughout the experiment and there was significant growth delay by 5 days (*P < 0.05) B, Images of GFP radiance were taken the same day as the caliper measurements. C, A significant correlation (*P < 0.05) is observed when the fold-change in tumor volume over time is compared to the fold-change in GFP signal over time in the group treated with 40 mg/kg of sunitinib.

Fig. 2 — Nude mice implanted with MDA-MB-435-GFP show correlation between tumor growth delay and GFP radiance. Nude mice (n=5 per group) were injected with MDA-MB-435-GFP tumor cells and were given vehicle control or 40 mg/kg of sunitinib once daily for five days. A, Tumor volumes were measured by caliper throughout the experiment and there was significant growth delay by 5 days (*P < 0.05) B, Images of GFP radiance were taken the same day as the caliper measurements. C, A significant correlation (*P < 0.05) is observed when the fold-change in tumor volume over time is compared to the fold-change in GFP signal over time in the group treated with 40 mg/kg of sunitinib.