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. Author manuscript; available in PMC: 2010 Oct 15.

Published in final edited form as: Clin Cancer Res. 2009 Oct 13;15(20):6421–6429. doi: 10.1158/1078-0432.CCR-09-0945

Fig. 4 — Nude mice implanted with MCF-7 show increased peptide binding relative to control. Nude mice (n=4 per group) were injected with MCF-7 tumor cells and were given vehicle control, 4 mg/kg or 40 mg/kg of sunitinib once daily for five consecutive days. A, Tumor volumes were measured by caliper daily (*P < 0.05). B, Peptide-dye complexes were injected 4 hours after the fifth day of treatment, and the mice were imaged at various intervals. Shown are representative images at 48 hours after peptide injection. C, Radiance was quantified from the images taken at time intervals after peptide injection (*P < 0.05) D, Radiance of tumor at 24 hours after peptide injection was correlated with a change in tumor volume on day 11 (*P < 0.05).

Fig. 4 — Nude mice implanted with MCF-7 show increased peptide binding relative to control. Nude mice (n=4 per group) were injected with MCF-7 tumor cells and were given vehicle control, 4 mg/kg or 40 mg/kg of sunitinib once daily for five consecutive days. A, Tumor volumes were measured by caliper daily (*P < 0.05). B, Peptide-dye complexes were injected 4 hours after the fifth day of treatment, and the mice were imaged at various intervals. Shown are representative images at 48 hours after peptide injection. C, Radiance was quantified from the images taken at time intervals after peptide injection (*P < 0.05) D, Radiance of tumor at 24 hours after peptide injection was correlated with a change in tumor volume on day 11 (*P < 0.05).