Table 1.
Baseline characteristics of LITE participants stratified by cohort (ARIC or CHS) and VTE case-control status.
| ARIC | CHS | ||||
|---|---|---|---|---|---|
| Controls | Cases | Controls | Cases | ||
| N | 624 | 255 | 380 | 179 | |
|
Demographics (matching factors) |
|||||
| Age (SD) | 55.9 (5.6) | 55.9 (5.5) | 73.1 (5.6) | 73.0 (5.5) | |
| Black Race (%) | 31.3 | 31.8 | 19.5 | 23.5 | |
| Male Gender (%) | 42.8 | 42.8 | 43.4 | 45.3 | |
| Physiologic Characteristics | |||||
| BMI (SD) | 28.0 (5.2) | 29.7 (5.8) | 26.5 (4.5) | 28.3 (5.3) | |
| Prevalent Diabetes (%) | 10.2 | 14.9 | 13.4 | 18.4 | |
| Prevalent CHD (%) | 5.2 | 7.2 | 13.7 | 10.6 | |
| VTE Genetic Risk Factors | |||||
| Factor V Leiden (%) | 2.9 | 10.9 | 3.4 | 7.9 | |
| Prothombin 20210A (%) | 2.0 | 2.1 | 1.7 | 6.1 | |
| Non-O Blood Type (%) | 53.8 | 67.0 | 52.3 | 64.6 | |
| Hemostatic Factors | |||||
| Factor VII (%, SD) | 118 (27) | 122 (30) | 123 (29) | 124 (30) | |
| Factor VIII (%, SD) | 131 (39) | 149 (48) | 122 (37) | 130 (43) | |
| Factor IX (%, SD) | 140 (30) | 146 (31) | 150 (31) | 154 (30) | |
| Factor X (%, SD) | 139 (29) | 141 (35) | 138 (30) | 139 (33) | |
| Factor XI (%, SD) | 135 (34) | 141 (37) | 126 (32) | 133 (33) | |
| Fibrinogen (mg/dL, SD) | 305 (61) | 308 (66) | 325 (66) | 313 (65) | |
| D-dimer* (ug/mL) | 0.35 | 0.42 | 0.52 | 0.66 | |
| vWF (%, SD) | 118 (47) | 140 (57) | -- | -- | |
| aPTT (seconds, SD) | 29.1 (2.8) | 28.0 (3.3) | -- | -- | |
| Peak Thrombin Generation | |||||
| Mean (nM, SD) | 107 (91) | 123 (97) | 245 (121) | 272 (149) | |
| Median (nM) | 80 | 98 | 232 | 253 | |
*
Geometric mean