Table 3.

Univariate and Multivarite Analyses of Risk Factors for CMV infection in CMV high-risk group

	CMV infection*				CMV high-grade infection*
Factors	Univariate HR (95%CI)	P	adj. HR (95%CI)	P	Univariate HR (95%CI)	P	adj. HR (95%CI)	P
NM-HCT	0.9 (0.7-1.0)	.08	0.9 (0.7-1.0)	.14	0.5 (0.4-0.7)	<.0001	0.7 (0.5-0.9)	.02
Recipient age ≤41 yrs	1.3 (1.1-1.4)	<.001	1.5 (1.3-1.7)	<.0001	0.9 (0.8-1.1)	.46	-	-
Recipient Race (other than Caucasian)	1.2 (1.0-1.4)	.01	1.1 (0.9-1.4)	.23	1.2 (1.0-1.6)	.08	1.4 (1.1-1.9)	<.01
Donor CMV positive	1.0 (0.9-1.1)	.56	-	-	0.7 (0.6-0.9)	.002	0.7 (0.6-0.9)	<.01
Related Donor	0.8 (0.7-0.9)	<.0001	0.9 (0.7-1.2)	.46	0.7 (0.5-0.8)	.0001	0.6 (0.4-1.0)	.04
HSV1 positive (recipient)	0.7 (0.5-0.8)	<.001	0.6 (0.5-0.8)	<.001	1.0 (0.7-1.6)	.92	-	-
Acute GVHD (III or IV)	1.5 (1.3-1.8)	<.0001	1.4 (1.2-1.6)	<.0001	2.2 (1.8-2.8)	<.0001	1.8 (1.4-2.3)	<.0001
Year of transplant
1995-1997	1.0		1.0		1.0		1.0
1998-2000	0.8 (0.7-1.0)	.01	0.8 (0.7-1.0)	.01	0.7 (0.5-0.9)	.006	0.7 (0.5-0.9)	<.01
2001-2003	0.8 (0.7-1.0)	.02	0.9 (0.7-1.1)	.20	0.5 (0.4-0.7)	<.0001	0.6 (0.4-0.8)	<.001
2004-2005	0.8 (0.7-1.0)	.04	0.8 (0.6-1.0)	.05	0.4 (0.3-0.5)	<.0001	0.4 (0.3-0.6)	<.0001

adj. HR: adjusted hazard ratio; CI: confidence interval; NM-HCT: nonmyeloablative allogeneic hematopoietic stem cell transplantation; CMV: cytomegalovirus. HSV1: herpes simplex virus type1; GVHD: graft-versus-host disease. The factors which were statistically significant in either multivariate model of CMV infection or high-grade CMV infection, and NM-HCT are displayed.

^*Total sample size of CMV high-risk patients is 1571.