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. Author manuscript; available in PMC: 2010 Mar 17.
Published in final edited form as: Oncogene. 2009 Jul 13;28(37):3286–3295. doi: 10.1038/onc.2009.187

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SV-BikDD treatment had no systemically acute toxicity compared with CMV-BikDD treatment in immunity complete mice. Male Balb/c mice were given single dose of 50 µg plasmid DNA in a liposomal complex via the tail vein injection (n = 5 mice/group). (A) Serum level of AST and ALT in mice was monitored after plasmid DNA injection. Error bars indicate SEM. (B) In vivo apoptosis of tissue specimens was detected by TUNEL assay and was quantified % of apoptotic cells from 4 fields. ** indicated p value < 0.01.