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. Author manuscript; available in PMC: 2009 Oct 19.
Published in final edited form as: Circ Res. 2008 Jul 24;103(5):545–553. doi: 10.1161/CIRCRESAHA.108.176867

Figure 1.

Figure 1

Hypoxic vasodilation (≈1% O2) by native human RBCs of mouse aortic segments, precontracted with phenylephrine (PE). A, Lack of effect of endothelial denudation or inhibition of NOS activity with L-NAME. Vasorelaxation was greatly attenuated by the guanylate cyclase inhibitor ODQ (n=9 to 34). *P<0.05. B and C, Representative examples of the elimination of acetylcholine (ACh)-induced vasorelaxation following endothelial removal versus preserved RBC-induced vasorelaxation.