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. Author manuscript; available in PMC: 2009 Oct 19.
Published in final edited form as: Circ Res. 2008 Jul 24;103(5):545–553. doi: 10.1161/CIRCRESAHA.108.176867

Figure 3.

Figure 3

Hypoxic vasodilation by native human RBCs of mouse aortic segments. A, Lack of effect of genetic elimination of eNOS (eNOS-/-). Elimination of iNOS (iNOS-/-), or nNOS (nNOS-/-) was associated with enhanced vasorelaxation. Vasorelaxation was greatly attenuated following treatment with the guanylate cyclase inhibitor ODQ in all cases (n=6 to 29). *P<0.05. B through D, Representative tracings illustrate the lack of effect of eNOS elimination and the enhancement of relaxation by nNOS and iNOS elimination.