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. Author manuscript; available in PMC: 2009 Oct 19.
Published in final edited form as: Circ Res. 2008 Jul 24;103(5):545–553. doi: 10.1161/CIRCRESAHA.108.176867

Figure 5.

Figure 5

PO2 dependence of vasoconstriction by native human RBCs of rabbit aortic segments. RBC-induced contraction terminated the relaxation at ≈1% O2 and exhibited latencies at ≈21% O2 (in the absence of relaxation) that were indistinguishable from the latencies of relaxation at ≈1% O2. Contractions were greater at ≈21% O2 than at ≈1% O2 and greatly attenuated by endothelium removal and by ODQ (n=9 to 36). *P<0.05. Representative examples illustrate the attenuation of vasoconstriction by hypoxia, denudation, and exposure to ODQ.