Table 5.
SNPs in genes selected by gene set analysis for relationship with bladder cancer survival
| Function | SNP | Genotype | Cases |
Deaths |
Bladder cancer HR (95% CI) |
Log rank test p value |
||
|---|---|---|---|---|---|---|---|---|
| N | % | N | % | |||||
| Transription factor | GATA3_29 | <0.001 | ||||||
| Growth control | rs528778 | wt | 261 | 62 | 104 | 61 | 1.0 (ref) | |
| Epithelial cell differentiation | g.IVS4+582C>T | het | 150 | 34 | 51 | 30 | 0.9 (0.67–1.3) | |
| var | 8 | 2 | 16 | 9 | 2.8 (1.6–5.0) | |||
| any var | 158 | 36 | 67 | 39 | 1.1 (0.8–1.5) | |||
| Interleukin 8 receptor | IL8RB_01 | 0.003 | ||||||
| rs1126579 | wt | 194 | 47 | 56 | 33 | 1.0 (ref) | ||
| g.Ex3+1235T>C | het | 173 | 42 | 82 | 48 | 1.7 (1.2–2.5) | ||
| var | 50 | 12 | 34 | 20 | 1.7 (1.1–2.8) | |||
| any var | 233 | 34 | 116 | 68 | 1.7 (1.2–2.5) | |||
| Mitotic kinase | PLK1_15 | 0.1 | ||||||
| Spindle formation | rs40076 | wt | 260 | 62 | 91 | 53 | 1.0 (ref) | |
| g.IVS3+26A>G | het | 138 | 33 | 70 | 41 | 1.2 (0.8–1.7) | ||
| var | 21 | 5 | 10 | 6 | 1.0 (0.5–2.1) | |||
| any var | 159 | 38 | 80 | 47 | 1.2 (0.8–1.6) | |||
| Glucuronidation | UGT1A1_24 | 0.1 | ||||||
| Lipophilic molecules | rs1042640 | wt | 270 | 65 | 93 | 55 | 1.0 (ref) | |
| g.Ex5−402G>C | het | 123 | 30 | 67 | 40 | 1.4 (1.0–2.0) | ||
| var | 22 | 5 | 8 | 5 | 1.4 (0.6–3.1) | |||
| any var | 155 | 35 | 75 | 45 | 1.4 (1.0–2.0) | |||
| Progesterone receptor | PGR_05 | 0.005 | ||||||
| rs613120 | wt | 120 | 29 | 34 | 20 | 1.0 (ref) | ||
| g.IVS2−1671T>C | het | 207 | 50 | 81 | 47 | 1.2 (0.8–1.9) | ||
| var | 91 | 22 | 57 | 33 | 1.4 (0.9–2.3) | |||
| any var | 298 | 77 | 138 | 80 | 1.3 (0.8–2.0) | |||
| Mitotic kinase | AURKA/STK6_06 | 0.1 | ||||||
| Chromosome distribution | rs6024840 | wt | 176 | 56 | 68 | 47 | 1.0 (ref) | |
| g.IVS7−80T>C | het | 123 | 39 | 70 | 48 | 1.4 (1.0–2.1) | ||
| var | 15 | 5 | 8 | 5 | 1.1 (0.5–2.5) | |||
| any var | 138 | 44 | 78 | 53 | 1.4 (1.0–2.0) | |||
| Telomerase | TERT_02 | 0.1 | ||||||
| rs6024840 | wt | 158 | 39 | 82 | 48 | 1.0 (ref) | ||
| g.IVS7−80T>C | het | 197 | 48 | 75 | 44 | 0.8 (0.6–1.1) | ||
| var | 55 | 13 | 15 | 8 | 0.5 (0.3–1.0) | |||
| any var | 252 | 61 | 90 | 52 | 0.8 (0.5–1.0) | |||
| Apoptosis | CASP9_01 | 0.003 | ||||||
| rs1052576 | wt | 203 | 50 | 55 | 34 | 1.0 (ref) | ||
| g.Ex5+32A>G | het | 148 | 36 | 77 | 46 | 1.3 (0.9–2.0) | ||
| p.Q221R | var | 59 | 14 | 35 | 21 | 1.4 (0.8–2.4) | ||
| any var | 207 | 50 | 112 | 67 | 1.3 (0.9–2.0) | |||
Analyses were adjusted for gender, age, smoking, treatment, tumor stage, grade, tumor size. Genotype data were missing for GATA3_29 27 cases; IL8RB_01 28 cases; PLK1_15 27 cases; UGT1A1_24 34 cases; PGR_05 27 cases; AURKA 157 cases; TERT_02 35 cases; CASP9_01 40 cases
wt wildtype, het heterozygous, var variant, any variant heterozygous and variant, g. gene, Ex exon, p. protein