Table 2.

Statistical results, hazard analysis for Metastisis Free Survival, Time to Local Failure, and Overall Survival. Summary of Cox proportional hazard ratio analysis showing significant perfusion/permeability predictors of clinical outcome determined with signal based DCE-MRI. The pre washout rate was predictive for metastasis free survival and overall survival while AUC t-max was predictive in time to local failure. For the post image analysis all the AUC calculation and the washin rates were predictive of metastasis free survival and overall survival. The pre pHe, the difference in pHe between pre and post therapy, and heating duration were also predictive of metastasis free survival and overall survival. (overall survival = overall survival, MFS = metastasis free survival, TFL = tumor local failure, pHe = extracellular pH, pHi = interstitial pH)

			MFS		TLF		OS
	Parameter	I.C	HR	p-value	HR	p-value	HR	p-value
PRE n=37	Grade	H vs. L	1.63 (1.1–2.4)	0.010	1.36 (0.8–2.3)	0.230	1.65 (1.1–2.4)	0.008
	Volume	27.9cc	1.15 (1.0–1.3)	0.049	1.05 (0.8–1.3)	0.620	1.16 (1.0–1.3)	0.040
	AUC 60	0.3	0.80 (0.6–1.1)	0.220	0.88 (0.6–1.4)	0.582	0.81 (0.6–1.2)	0.247
	AUC 90	0.3	0.80 (0.6–1.1)	0.209	0.87 (0.6 –1.4)	0.562	0.81 (0.6 1.1)	0.234
	AUC t-max	0.3	0.89 (0.7–1.1)	0.310	0.66 (0.5–0.9)	0.020	0.89 (0.7–1.1)	0.320
	Washin	0.1	0.89 (0.7–1.1)	0.331	0.86 (0.6–1.2)	0.381	0.89 (0.7–1.1)	0.338
	Washout	1.4	0.68 (0.5–0.9)	0.015	0.87 (0.6–1.3)	0.500	0.67 (0.5–0.9)	0.012
POST n=17	AUC 60	0.3	0.44 (0.3–0.7)	0.001	0.84 (0.5–1.5)	0.540	0.49 (0.3–0.8)	0.001
	AUC 90	0.3	0.45 (0.3–0.7)	0.001	0.85 (0.5–1.5)	0.550	0.49 (0.3–0.8)	0.001
	AUC t-max	0.4	0.46 (0.3–0.8)	0.002	0.65 (0.4–1.2)	0.170	0.46 (0.3–0.8)	0.001
	Washin	0.1	0.55 (0.4–0.9)	0.004	0.76 (0.5–1.3)	0.270	0.53 (0.3–0.8)	0.002
	Washout	1.7	0.82 (0.5–1.3)	0.414	1.16 (0.6–2.1)	0.65	0.82 (0.5–1.3)	0.402
PH	pHi-Pre (n=30)	H vs. L	0.54(0.2–1.3)	0.150	0.49(0.2–1.5)	0.199	0.58(0.3–1.3)	0.199
	pHi@24hr-pHi-Pre (n=15)	H vs. L	1.44(0.5–4.6)	0.538	7.70(0.9–66.2)	0.063	1.41(0.4–4.5)	0.565
	pHe-Pre (n=30)	H vs. L	0.29(0.1–0.7)	0.005	0.84(0.27–2.60)	0.767	0.36(0.2–0.8)	0.013
	pHe@24hr-pHe-Pre (n=24)	H vs. L	2.87(1.1–7.6)	0.034	1.59(0.5–5.5)	0.465	2.54(1.0–6.7)	0.061
HTmin	Total Duration of Heat (min)		1.28(1.1–1.5)	0.007	1.18(0.9–1.5)	0.149	1.32(1.09–1.60)	0.004

MFS = metastasis free survival , TLF = time to local failure, OS = overall survival

I.C = Incremental change (of respective unit)

HR = hazard ratio (confidence interval)

AUC 60 = area under the curve integrated up to 60 sec

AUC 90 = area under the curve integrated up to 90 sec

AUC t-max = area under the curve integrated up to time to muscle peak