Table 4.

Summary analysis showing the relationship between the MRI parameters measured to pH parameters. pHi = interstitial pH and pHe = extracellular pH. Only the difference between pHe pre and post therapy was found correlate with post washout values. Bold and shaded cells were significant and bolded image parameters were the ones significant in predicting outcome as shown in Table 1

		pHi-Pre		pHi@24hr - pHi-Pre		pHe-Pre		pHe@24hr - pHe-Pre
		Spearman	p -value	Spearman	p -value	Spearman	p -value	Spearman	p -value
Pre	AUC60	0.034	0.868	0.169	0.563	0.023	0.912	0.02	0.93
	AUC90	0.046	0.818	0.143	0.626	0.034	0.871	0.01	0.966
	AUC t-max	−0.163	0.417	0.037	0.899	0.099	0.63	0.098	0.665
	Washin	0.006	0.976	0.174	0.553	0.032	0.877	0.132	0.56
	Washout	0.027	0.894	−0.486	0.078	0.149	0.467	−0.014	0.95
Post	AUC 60	−0.118	0.676	−0.036	0.916	0.256	0.358	0.086	0.761
	AUC 90	−0.125	0.657	0.036	0.916	0.256	0.358	0.125	0.657
	AUC t-max	−0.236	0.398	0.036	0.916	0.225	0.42	0.254	0.362
	Washin	−0.236	0.398	0.173	0.612	0.32	0.245	0.293	0.29
	Washout	−0.643	0.01	0.182	0.593	−0.288	0.298	0.736	0.002
HT(min)	HT(min)	0.066	0.744	0.077	0.794	−0.204	0.317	−0.213	0.342

AUC 60 = area under the curve integrated up to 60 sec

AUC 90 = area under the curve integrated up to 90 sec

AUC t-max = area under the curve integrated up to time to muscle peak