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Several viral miRNAs show sequence similarity but lack a conserved miRNA seed region. Alignment of miRNAs encoded by the related polyomaviruses SV40 and JCV (A) or by the related herpesviruses HSV-1 and HSV-2 (B). Only in the case of HSV-1 miR-H2 and HSV-2 miR-H2 is conservation of the miRNA seed region observed (in gray), although there is considerable conservation outside of the seed in the other miRNAs listed. See the text for detailed discussion.
