Skip to main content
. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Curr Opin Struct Biol. 2009 Jul 23;19(4):473–482. doi: 10.1016/j.sbi.2009.07.003

Figure 5.

Figure 5

Docking of C34 into the N-trimeric core was used to choose residues for replacement by D-residues. The side chains indicated in red face away from the core and can be replaced with amino acids of opposite chirality. The docking energies provide additional guidance for positions that do not contribute to the binding affinity. Based on this structure C34M3 had D-residues inserted at positions 2, 27 and 31 and had potency comparable to C34 but was more soluble and more stable to protease digestion. Figure from [46].