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. 2009 Jun 1;23(11):1247–1269. doi: 10.1101/gad.1792809

Figure 1.

Figure 1.

Mammalian RNAPII termination at protein-coding genes. Poly(A) site recognition leads to changes in the EC. Some factors associated with RNAPII through elongation that may function as anti-terminators are released (Paf1C, PC4) upon passage through the poly(A) site. At the same time, other factors, such as Xrn2, are recruited to the EC. After cleavage, Xrn2, most likely recruited by p54nrb/PSF, degrades the downstream RNA, “catches up” with RNAPII, and, perhaps with the aid of the helicase SETX, terminates transcription by releasing RNAPII from the template DNA. Involvement of chromatin remodeling factors and pausing sequences and factors are depicted. The RNAPII subunits Rpb3 and Rpb11 are also shown to play a role in termination by perhaps transducing a “termination signal.” The possible involvement of SR proteins in termination is also indicated.