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(A) Time-response relationships for hoiamide A reversal of batrachotoxin (30 nM)-induced elevation of neuronal [Na+]i; (B) Nonlinear regression analysis of the hoiamide-induced reversal of the integrated SBFI response [area under the curve (AUC)] to batrachotoxin (30 nM) in neocortical neurons. Histogram represents the responses to batrachotoxin (30 nM) and hoiamide A (30 μM) alone. These experiments were performed twice in triplicate with similar results.
