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. Author manuscript; available in PMC: 2010 Apr 9.
Published in final edited form as: J Med Chem. 2009 Apr 9;52(7):1912–1921. doi: 10.1021/jm801445c

Table 1.

Quercetin derivatives. The substituent is an H unless otherwise noted.

graphic file with name nihms-103785-t0010.jpg
Cmpd R3 R5 R7 R3′ R4′ HSP70
inhibition		 HSP27
phosphorylation
Quercetin +++ +++
 D1 CH2CO2CH3 ++ -
 D2 CH3 +++ -
 D3 CH3 + -
 D4 CH3 - -
 D5 CH2CO2H - -
 D6 CH3 - -
 D7 CH3 +++ +++
 D8 CH2CO2CH3 - -
 D9 CH2CO2H - -
 D10 CH2CO2CH3 +++ +++