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. Author manuscript; available in PMC: 2010 Apr 9.
Published in final edited form as: J Med Chem. 2009 Apr 9;52(7):1912–1921. doi: 10.1021/jm801445c

Table 2.

IC50 values (μM) for inhibition of CK2 and CamKII by quercetin and derivatives D1-D10.

Q D1 D2 D3 D4 D5
CK2 5.6 ± 1.2 53 ± 3.7 0.50 ± 0.01 >100 0.83 ± 0.10 2.45 ± 0.25
CamKII 3.3 ± 0.6 6.3 ± 1.3 0.91 ± 0.25 16.4 ± 1.9 >100 >100
HSP70 +++ ++ +++ + - -
D6 D7 D8 D9 D10
CK2 >100 9.7 ± 1.4 >100 9.7 ± 3.6 0.85 ± 0.30
CamKII 4.0 ± 1.1 8.9 ± 0.3 69 ± 6.0 9.3 ± 1.8 9.1 ± 0.1
HSP70 - +++ - - +++