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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Curr Mol Med. 2009 May;9(4):470–482. doi: 10.2174/156652409788167159

Fig. (3). Proposed role of FANCJ in resolving G4 quaduplex DNA during replication.

Fig. (3)

According to the model presented, the replication fork moves in from the left toward the poly(G) sequences (in red). Single-stranded poly(G) sequences used as a template for lagging-strand DNA synthesis are postulated to occasionally give rise to stable secondary structures such as G4 structure. FANCJ helicase is recruited to unwind the G4 quadstructure, permitting polymerization using the template strand (in blue). Failure to resolve G-quadruplex DNA in FA-J cells results in genomic instability (dashed line in red).