. Author manuscript; available in PMC: 2010 Nov 1.

Published in final edited form as: J Clin Virol. 2009 Sep 12;46(3):259–264. doi: 10.1016/j.jcv.2009.08.002

Table 3.

Frequency of immune epitope mutations in HBV isolates of patients with different categories of BCP and pre-core mutations

	Th epitopes		CTL epitpes		B-cell epitopes

	Sum	Mean	Sum	Mean	Sum	Mean
BCP
Mutants (n=58)	134	2.31	51	0.88	107	1.84
Wild-type (n=11)	6	0.55	15	1.36	14	1.27
Pre-core
Mutants^* (n=66)	113	1.71	56	0.85	121	1.83
Wild-type (n=9)	11	1.22	5	0.56	12	1.33

These consist of isolates with A¹⁸⁹⁶ together with two other isolates with other mutations within pre-core region, one of which abolished the pre-core start codon, and the other made another stop codon in the second aa position of pre-core polypeptide.