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Effect of SK2 over-expression on anxiety and locomotion as measured in open field. SK2 over-expression enhanced time spent away from wall in a big open arena (A) without affecting the total distance traveled (B) Mean ± SEM. n = 12 animals per group. SK2 over-expression also increased the number of crossings made at the center of a smaller open field (C) Mean ± SEM. n = 5-6 animals per group; * p < 0.001, Student's t-test. Inset: Time profile for infusion and behavior.
