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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Biochim Biophys Acta. 2009 May 22;1791(8):806–815. doi: 10.1016/j.bbalip.2009.05.006

Figure 4.

Figure 4

Differences in oleic acid oxidation between human and mouse fibroblasts. A. Oleic acid oxidation in human VLCADD fibroblasts (D, white bar) compared to control fibroblasts (C, black bar), and VLCAD−/− and LCAD−/− mouse fibroblasts (white bars) compared to wild type fibroblasts (black bars), using 0.4% BSA and 100µM oleic acid. B. Oleic acid oxidation measured with 0.4% BSA and 0.1% BSA in fibroblasts of the VLCAD−/− and CAD−/− mouse compared with wild type fibroblasts. Differences between 0.1% and 0.4% treated cells were analyzed by a paired t test, ** denotes P < 0.01. C. C2-acylcarnitine production in fibroblasts of the LCAD−/− and wild type fibroblasts after 72 hr incubation with 100µM [U-13C]-oleic acid, in the presence of 0.4% BSA and 0.1% BSA. D. Oleic acid oxidation in soleus muscle of LCAD+/+ and LCAD−/− mice measured using 0.1% BSA and 100mM fatty acid. Differences were analyzed by an unpaired t test. ** denotes P < 0.01.