. Author manuscript; available in PMC: 2010 Feb 1.

Published in final edited form as: Ann Neurol. 2009 Feb;65(2):176–183. doi: 10.1002/ana.21559

Table 1.

Subject Demographic Characteristics

Characteristic	CDR 0	CDR > 0^a	P value
N	69	29
Age at LP, mean (SD), y	71.41 (8.62)	75.1 (5.0)	0.0337^*
Gender, F/M (% F)	52/17 (75%)	17/12 (59%)	0.6092
APOE genotype, % ε4+	41%	59%	0.4598
Education, mean (SD), y	15.7 (3.0)	14.0 (3.1)	0.0128^*
MMSE score (range 0-30), mean (SD)	29.32 (0.98)	25.24 (4.15)	<0.0001^*
nWBV, mean (SD), fractional ICV	0.765 (0.038)	0.728 (0.033)	<0.0001^*
HC, mean (SD), mm³^b	7084 (793)	6009 (1236)	<0.0001
CSF Aβ₄₀, mean (SD), pg/mL	10524 (3837)	10613 (3787)	0.9164
CSF Aβ₄₂, mean (SD), pg/mL	572 (208)	472 (186)	0.0275^*
CSF tau, mean (SD), pg/mL	334 (180)	534 (304)	<0.0001^*
CSF ptau₁₈₁, mean (SD), pg/mL	61 (27)	82 (46)	0.0059^*
CSF tau/Aβ₄₂, mean (SD)	0.684 (0.559)	1.363 (1.176)	<0.0002^*
CSF ptau₁₈₁/Aβ₄₂, mean (SD)	0.124 (0.087)	0.211 (0.197)	0.0030^*
Plasma Aβ₄₀, mean (SD), pg/mL^c	220 (113)	194 (81)	0.2942
Plasma Aβ₄₂, mean (SD), pg/mL^d	64 (120)	40 (44)	0.3137

CDR 0.5, n=21; CDR 1, n=8

CDR 0, n=58; CDR > 0, n=28

CDR 0, n=57; CDR > 0, n=27

Abbreviations: APOE, apolipoprotein E; CDR, clinical dementia rating; HC, hippocampal complex (combined left and right hippocampal formation); ICV, intracranial volume; LP, lumbar puncture; N, number; nWBV, normalized whole brain volume; v, volume; y, years;

statistically significant