Table 6.
Relative efficiency of parameter estimates under both the gene-environment interaction and gene-gene interaction models for case-parents triads
| Scheme | β1 = 0.405 | β2 = 0.405 | β3 = 0.405 | β4 = 0.693 | β5 = 1.100 |
|---|---|---|---|---|---|
| Gene-environment interaction model | |||||
| Full | 1.00 | 1.00 | 1.00 | – | 1.00 |
| 1 counter | 0.95 | 0.90 | 0.94 | – | 0.96 |
| 5 counter | 0.98 | 0.96 | 0.98 | – | 0.99 |
| 9 counter | 0.98 | 0.97 | 1.00 | – | 1.00 |
| 1 random | 0.52 | 0.51 | 0.48 | – | 0.48 |
| 5 random | 0.77 | 0.71 | 0.75 | – | 0.80 |
| 9 random | 0.85 | 0.84 | 0.84 | – | 0.86 |
| Gene-gene interaction model | |||||
| Full | 1.00 | 1.00 | 1.00 | – | 1.00 |
| 1 counter | 0.90 | 0.93 | 0.88 | – | 0.46 |
| 5 counter | 0.97 | 0.97 | 0.94 | – | 0.77 |
| 9 counter | 0.99 | 0.99 | 0.96 | – | 0.95 |
| 1 random | 0.47 | 0.49 | 0.49 | – | 0.40 |
| 5 random | 0.75 | 0.80 | 0.73 | – | 0.72 |
| 9 random | 0.87 | 0.82 | 0.81 | – | 0.79 |
The results are based on 1000 simulated datasets, each consist of 500 case-parents triads. The main effect of the environmental covariate β4 is unestimable from triads-only and thus omitted.