Table 9.

Log-odds ratio estimates (95% confidence intervals, p values) for gene-gene interactions between GH1 and IGF1 and between IGFBP3 and IGF1 under a log-additive model, by type of subjects included in the model

Subjects in model	Gene-gene interaction
	GH1	IGF1	GH1∗IGF1
Triads	–0.14 (–0.76 to 0.47, 0.64)	–0.46 (–1.09 to 0.18, 0.16)	0.22 (–0.34 to 0.77, 0.44)
Triads and Dyads	–0.10 (–0.60 to 0.40, 0.70)	–0.30 (–0.80 to 0.20, 0.24)	0.24 (–0.21 to 0.69, 0.30)
Cases and Controls	–0.01 (–0.32 to 0.31, 0.98)	0.06 (–0.28 to 0.40, 0.74)	–0.13 (–0.46 to 0.21,0.46)
Triads and Controls	–0.05 (–0.36 to 0.27, 0.76)	–0.07 (–0.41 to 0.27, 0.69)	–0.03 (–0.36 to 0.29, 0.84)
Triads, Dyads and Controls	–0.05 (–0.36 to 0.26, 0.75)	–0.07 (–0.41 to 0.26, 0.67)	0.01 (–0.32 to 0.34, 0.95)
	IGFBP3	IGF1	IGFBP3∗IGF1
Triads	0.70 (0.14 to 1.26, 0.01)	0.19 (–0.59 to 0.98, 0.63)	–0.33 (–0.89 to 0.23, 0.25)
Triads and Dyads	0.41 (–0.05 to 0.87, 0.09)	0.08 (–0.58 to 0.74, 0.81)	–0.09 (–0.53 to 0.35, 0.67)
Cases and Controls	0.14 (–0.18 to 0.45, 0.39)	0.06 (–0.36 to 0.47, 0.78)	–0.09 (–0.40 to 0.24, 0.58)
Triads, Cases and Controls	0.27 (–0.04 to 0.57, 0.09)	0.10 (–0.29 to 0.50, 0.61)	–0.16 (–0.47 to 0.16, 0.32)
Triads, Dyads, Cases and Controls	0.22 (–0.09 to 0.52, 0.16)	0.07 (–0.34 to 0.48, 0.73)	–0.09 (–0.40 to 0.22, 0.55)