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AMG0347 (500 μg/kg i.v.) causes hyperthermia in control mice, but not in Trpv1 KO mice. [Modified from Steiner AA, Turek VF, Almeida MC, Burmeister JJ, Oliveira DL, Roberts JL, Bannon AW, Norman MH, Louis JC, Treanor JJ, et al. (2007) Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors. J Neurosci 27:7459–7468. Copyright © 2007 Society for Neuroscience. Used with permission.].
