Fig. 8.
AMG0347 hyperthermia is independent of either basal colonic temperature or basal tail Tsk. AMG0347 (50 μg/kg i.v.) was injected in rats at Ta of 17, 24, or 28°C (A). At all Ta values tested, the drug induced hyperthermic responses of similar magnitude. When the response magnitude (the maximal increase in colonic temperature) for each rat was plotted against its basal (at the time of drug administration) colonic temperature (B) or against its basal Tsk (C), no positive correlation was found. [Modified from Steiner AA, Turek VF, Almeida MC, Burmeister JJ, Oliveira DL, Roberts JL, Bannon AW, Norman MH, Louis JC, Treanor JJ, et al. (2007) Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors. J Neurosci 27:7459–7468. Copyright © 2007 Society for Neuroscience. Used with permission.]