Table 2.

TRPV1 agonists: their potencies and their effects on deep T_b in rats and mice.

Name	In Vitro: EC50 in Different Species			In Vivo: Effect on Deep Tb
	Rat	Mouse	Human	Species	Dose and Route	Effect
	nM	nM	nM		mg/kg
AEA	350–1560a–c	3000d	520–550c,e,f	Rat	10–20 i.p.	↓g
				Mouse	10–40 i.v.	↓h,i
NADA	48c	—	26–63c,e,j	Mouse	10 i.p.	↓k
OEA	2000l	—	—	Rat	20 i.v.	↓m
				Mouse	10 i.v.	↓i
OLDA	1800n	258o	36j	—	—	—
CAP	10–42a–c,n	9–300d,o>	19–34c,e,f,j>	Rat	Varied	↓p
				Mouse	1–15 s.c.	↓q
RTX	0.17a	0.15o	—	Rat	Varied	↓p
				Mouse	0.0005–0.02 i.p., s.c.	↓r

↓, decrease in deep T_b; —, not studied.

^aRoss et al. (2001).

^bDi Marzo et al. (2001).

^cHuang et al. (2002).

^dRoberts et al. (2002).

^eDe Petrocellis et al. (2000).

^fDe Petrocellis et al. (2001).

^gCrawley et al. (1993).

^hAdams et al. (1998); Wiley et al. (2006).

ⁱWatanabe et al. (1999).

^jChu et al. (2003).

^kBisogno et al. (2000).

^lAhern (2003).

^mProulx et al. (2005). The effect on deep T_b, although not measured in this study, is an assumption based on the measured effect on heat expenditure.

ⁿSzolcsányi et al. (2004).

^oCorrell et al. (2004).

^p For review and references, see section IV.B.1.

^qde Vries and Blumberg (1989); Caterina et al. (2000).

^rde Vries and Blumberg (1989); Steiner et al. (2007).