Table 4.

Thermoregulatory responses to systemically or centrally applied CAP or heating in different models of CAP- or RTX-induced desensitization

Desensitization Model			Effects
Age group	Species	TRPV1 Agonist, Dose and Route	Hypothermia Induced by			Heat-Defense Responses to Whole-Body Heating
			Systemic CAP (0.05–16 mg/kg i.p., s.c., i.v.)	Intracerebral CAP (0.002–0.2 mg/kg)	Brain Heating
		mg/kg
Adult	Rat	CAP 20–310 i.p., s.c. or RTX 0.2 i.p.	↓a–d	↓d,e	↓d,g	↓a,b,f–i
	Mouse	CAP 45 s.c.	—	—	—	↓j
	Guinea pig	CAP 30–40 i.p.	↓b	—	—	↓b
Neonate	Rat	CAP 50–450 i.p., s.c.	↓c,k,l	↕c,l	↕g,l	↓g,h,m

↑, attenuation; ↕, no change; —, not studied.

^aSzolcsányi and Jancsó-Gá;bor (1973); Szikszay et al. (1982); Mills et al. (2008).

^bJancsó-Gábor et al. (1970a).

^cHajós et al. (1983).

^dJancsó-Gábor et al. (1970b).

^eSteiner et al. (2007).

^fCabanac et al. (1976), Obál et al. (1979, 1980, 1982); Benedek et al. (1983); Szolcsányi (1983).

^gObal et al. (1983).

^hObál et al. (1987).

ⁱSzékely and Romanovsky (1997).

^jSzelényi et al. (2004).

^kDonnerer and Lembeck (1983).

^lDib (1983).

^mHori and Tsuzuki (1981).