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. 2009 Sep;61(3):228–261. doi: 10.1124/pr.109.001263

Table 5.

TRPV1 antagonists

Name, Company IUPAC Name Structure
A-425619, Abbott 1-(5-Isoquinolinyl)-3-(4-(trifluoromethyl)benzyl)urea graphic file with name zpg003092269t501.jpg
A-889425, Abbott 1-(3-Methylpyridin-2-yl)-N-(4-trifluoromethyl-sulfonyl)phenyl)-1,2,3,6-tetrahydropyridine-4-carboxamide graphic file with name zpg003092269t502.jpg
ABT-102, Abbott (R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea graphic file with name zpg003092269t503.jpg
AMG0347, Amgen (2E)-N-(7-Hydroxy-5,6,7,8-tetrahydro-1-naphthalenyl)-3-(2-(1-piperidinyl)-6-(trifluoro-methyl)-3-pyridinyl)-2-propenamide graphic file with name zpg003092269t504.jpg
AMG1629, Amgen 3-Amino-5-((2-((2-methoxyethyl)amino)-6-(4-(trifluoromethyl)-phenyl)-4-pyrimidinyl)-oxy)-2(1H)-quinoxalinone graphic file with name zpg003092269t505.jpg
AMG2820, Amgen 8-((6-(4-(Trifluoromethyl)phenyl)-4-pyrimidinyl)oxy)-3-isoquinolinol graphic file with name zpg003092269t506.jpg
AMG3731, Amgen N-(4-(((3-(6-((2-Amino-1,3-benzothiazol-4-yl)oxy)-4-pyrimidinyl)-6-(trifluoromethyl)-2-pyridinyl)amino)methyl)-2-fluorophenyl)-methanesulfonamide graphic file with name zpg003092269t507.jpg
AMG 517, Amgen N-(4-((6-(4-(Trifluoromethyl)phenyl)-4-pyrimidinyl)oxy)-1,3-benzothiazol-2-yl)-acetamide graphic file with name zpg003092269t508.jpg
AMG7905, Amgen N-(6-(2-((Cyclohexylmethyl)amino)-4-(tri-fluoromethyl)phenyl)-4-pyrimidinyl)-1,3-benzothiazol-6-amine graphic file with name zpg003092269t509.jpg
AMG7988, Amgen 4-((6-(2-((2-(1-Piperidinyl)ethyl)amino)-6-(trifluoromethyl)-3-pyridinyl)-4-pyrimidinyl)-oxy)-1,3-benzothiazol-2-amine graphic file with name zpg003092269t510.jpg
AMG8163, Amgen tert-Butyl (2-(6-((2-(acetylamino)-1,3-benzothiazol-4-yl)oxy)-4-pyrimidinyl)-5-(trifluoromethyl)phenyl)-carbamate graphic file with name zpg003092269t511.jpg
AMG8562, Amgen (2E)-N-((2R)-2-Hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(1-piperidinyl)-4-(trifluoromethyl)phenyl)-2-propenamide graphic file with name zpg003092269t512.jpg
AMG8563, Amgen (2E)-N-((2S)-2-Hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(1-piperidinyl)-4-(trifluoromethyl)phenyl)-2-propenamide graphic file with name zpg003092269t513.jpg
AMG9810, Amgen (2E)-3-(4-tert-Butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-propenamide graphic file with name zpg003092269t514.jpg
BCTC, Neurogen N-(4-tert-Butylphenyl)-4-(3-chloro-2-pyridinyl)-1-piperazinecarboxamide graphic file with name zpg003092269t515.jpg
Comp. 41, Johnson & Johnson 4-(3-(Trifluoromethyl)-2-pyridinyl)-N-(5-(tri-fluoromethyl)-2-pyridinyl)-1-piperazine-carboxamide graphic file with name zpg003092269t516.jpg
Comp. G, Amgen 1-(5-Chloro-6-((3R)-3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzimidazol-2-yl)-1-piperazinyl)-3-pyridinyl)-1,2-ethanediol graphic file with name zpg003092269t517.jpg
Comp. H, Amgen 2-((2,6-Dichlorophenyl)-amino)-N-(4-(trifluoro-methyl)phenyl)-1,3-thiazole-4-carboxamide graphic file with name zpg003092269t518.jpg
JYL 1421,a Schwarz Pharma N-(4-((((4-tert-Butylbenzyl)carbamothioyl)-amino)methyl)-2-fluorophenyl)methanesulfon-amide graphic file with name zpg003092269t519.jpg
a

This compound was also published as SC0030 by Suh et al. (2003).