Fig. 8.

Therapeutic effects of exogenous infusion of VIP (20 nmol/day) by a 7-day osmotic pump on colonic inflammation induced by 68 mg/kg of TNBS (TNBS68). A: TNBS68 inflammation significantly reduced the rate of increase in weight gain during the 7-day postinflammation period. VIP infusion for 7 days by an osmotic pump, as described above, significantly improved the gain in weight, when compared with that attributable to TNBS68 inflammation. B: induction of TNBS68 inflammation significantly reduced food intake, starting with day 1 of inflammation and lasting at least until day 7. VIP infusion ,as described above, significantly reversed the decrease in food intake. *P < 0.05 vs. control; #P < 0.05 vs. TNBS68 group. N = 3 to 5 in each group.