Table 3.
Effects of losartan on arterial pressure, renal function, and the systemic renin-angiotensin system
| Baseline | Day 7 | Day 30 | Day 120 | Day 270 | End of Treatment | |
|---|---|---|---|---|---|---|
| Systolic arterial pressure, mmHg | 120 (116–128) | 113 (110–122) | 120 (112–124) | 120 (113–125) | 120 (113–125) | 120 (112–121) |
| Diastolic arterial pressure, mmHg | 70 (69–78) | 70 (65–75) | 70 (67–76) | 70 (66–76) | 70 (66–77) | 70 (68–76) |
| Mean arterial pressure, mmHg | 90 (85–94) | 83 (80–90)* | 87 (83–92) | 88 (80–90) | 88 (80–90) | 87 (80–90) |
| Plasma renin activity, ng·ml−1·h−1† | 0.16 (0.08–0.25) | 1.13 (0.28–1.99) | 0.96 (0.22–1.69) | 1.01 (0.31–1.91) | 1.06 (0.32–1.8) | 0.89 (0.33–1.46) |
| Serum angiotensin II, pg/ml* | 10.04 (7.4–12.7) | 18.65 (10.7–26.6) | 21.87 (9.4–34.4) | 22.8 (8.9–37.8) | 23.9 (8.5–39.3) | 20.6 (11.8–29.4) |
| Serum creatinine, mg/dl | 1.0 (0.9–1.1) | 1.0 (0.9–1.0) | 1.0 (0.9–1.1) | 1.0 (0.9–1.1) | 1.0 (0.9–1.1) | 1.0 (0.9–1.1) |
Results are expressed as median (95% CI).
*
P < 0.001 vs. baseline;
†
P < 0.0001 vs. baseline.