. 2009 Oct;297(4):G726–G734. doi: 10.1152/ajpgi.00162.2009

Table 5.

Hepatic expression of genes involved in liver fibrogenesis in normal livers compared with patients with CHC before and after treatment with losartan

Gene Name	CHC Before Treatment (n = 14)	CHC After Treatment (n = 14)	CHC After Treatment vs. Before Treatment
Gene Name	CHC Before Treatment (n = 14)	CHC After Treatment (n = 14)	Fold	P	Corrected P value^†
Fibrogenic
Procollagen α1(I)^*	21.6±4.6	15.1±2.3	0.69	0.0464	0.047
Procollagen α1(IV)^*	19.0±3.7	14.7±2.7	0.77	0.0277	0.039
MMP-2^*	7.0±1.5	5.1±1.3	0.73	0.0392	0.046
ut-PA^*	0.96±0.13	0.56±0.10	0.60	0.0277	0.036
TIMP-1^*	78.1±15.5	67.2±11.8		0.0747
TGF-β₁^*	19.0±4.2	17.90±3.9		0.6496
ACE-1^*	1.06±0.32	1.02±0.28		0.3821
ACE-2^*	3.2±0.78	4.5±1.48		0.9721
AT1 receptor	2.00±0.24	1.63±0.29		0.1961
Prooxidant
NOX-1	NE	NE
NOX-2 (gp91^phox)	36.9±5.8	32.3±4.3		0.2487
NOX-3	NE	NE
NOX-4 (Renox)^*	0.10±0.02	0.10±0.02		1.0000
NOX-5	NE	NE
p22^phox^*	30.4±3.9	29.3±3.5		0.8613
Duox-1	0.05±0.01	0.05±0.01		0.9372
Duox-2	0.05±0.01	0.07±0.03		0.6947
NOXA-1 (p67^phox)^*	0.73±0.07^†	0.57±0.05	0.74	0.0107	0.031
NOXO-1 (p47^phox)^*	0.74±0.06^†	0.53±0.04	0.71	0.0119	0.031
Rac-1^*	2.90±0.43	2.39±0.39	0.81	0.0159	0.031
Rac-2^*	4.48±0.77	4.31±0.52		0.8613
Catalase^*	308±32	252±24	0.82	0.0046	0.031
Cytochrome P-450 2E1^*	2817±289	2204±192	0.78	0.0131	0.031
SOD-2	150±27	146±14		0.4454
HO-1	21.3±2.7	18.9±3.0		0.1961
Inflammatory
TNF-α^*	1.23±0.23	1.06±0.20		0.1961
GRO-α	3.9±1.0	4.00±1.1		0.9721
IL-6	0.07±0.02	0.08±0.02		0.8139
MCP-1	6.0±1.4	5.19±1.0		0.2787
Apoptotic
Fas ligand	0.97±0.20^*	0.82±0.13		0.5067
Bcl-2	2.81±0.54^*	2.64±0.48		0.5767

Results are expressed as 2⁻^ΔΔCt. Values are means ± SE. CHC, chronic hepatitis C; NE, not expressed.

P < 0.05 vs. normal liver;

^†

Corrected P values after correction for multiple comparisons.