Table 2.
The inhibitors used in this study and their respective targets
| Inhibitor Name | Target Signal Molecules | |
|---|---|---|
| Chemical Inhibitors | ||
| Pertussis toxin | Gαi family and GαΔ6qi5myr | |
| PD 98059 | ERK1/2 | |
| Genistein | Tyrosine kinase | |
| AG 1478 | EGFR | |
| RGS-p115RhoGEF | Gα12/13 family | |
| RGS-GRK2 | Gαq family | |
| C3-exoenzyme | Rho family GTPase | |
| Y-27632 | Rho kinase | |
| SB202190 | p38 MAPK | |
| LY294002 | Phosphoinositide-3 kinase | |
| Edelfosine | Phosphatidylinositol-specific PLC | |
| Gö 6976 | PKCα, PKCβI, PKCγ, PKD1 (PKCμ) | |
| PKD2, and PKD3 (PKCν) | ||
| U-73122 | PLCβ | |
| FTI-277 | Farnesyltransferase | |
| Gene Inhibitors | ||
| RGS-p115RhoGEF | Gα12/13 family | |
| RGS-GRK2 | Gαq family (except Gα15/16) | |
The inhibitors were used as described in materials and methods.