Fig. 2.

Skeletal muscle myopathy in unexercised SUR2 mutant mice. Quadriceps muscle was isolated from sedentary and exercised cohorts of control (n = 5 and 5, respectively) and SUR2 mutant mice (n = 4 and 4, respectively). A: representative photomicrographs of paraffin-embedded quadriceps muscle from sedentary and exercised cohorts of control and SUR2 mutant mice. Sedentary SUR2 mutant mice display skeletal muscle myopathy that does not worsen with exercise. Myopathic fibers were typically present in foci around the muscle periphery. (Scale bar = 200 μm or 10 μm). B: myopathic fibers are increased in SUR2 mutant mice. *P < 0.05 vs. sedentary control, #P < 0.05 vs. exercised control by Student's t-test. C: centrally nucleated fibers are increased in SUR2 mutant muscle. *P < 0.001 vs. sedentary control, #P < 0.001 vs. exercised control, $P < 0.01 vs. sedentary SUR2 mutant, all by ANOVA and Tukey's multiple-comparison tests. D: quantification of total fiber number. E: quantification of fiber size.