Fig. 5.

Serum glucose levels are not altered in exercised SUR2 mutant mice. A: baseline “fed” serum glucose levels were similar for control and SUR2 mutant mice. Exercise significantly reduced baseline serum glucose in both control and SUR2 mutant mice. *P < 0.05 vs. sedentary control, #P < 0.01 sedentary SUR2 mutant both by ANOVA. B: serum glucose was measured after a 16-h overnight fast. Fasting blood glucose was significantly reduced in sedentary SUR2 mutant mice. *P < 0.05 vs. sedentary control, #P < 0.05 vs. exercised SUR2 mutant both by ANOVA. C: following an overnight fast, glucose challenge tests were conducted (2 mg/g ip glucose). Response to glucose challenge was similar between sedentary control and SUR2 mutant mice. Exercise significantly improved response to glucose challenge in control mice, but not SUR2 mutant mice. *P < 0.05 by two-way ANOVA comparison of control cohorts.