Table 2.

Effect of treatments on body weight, soleus wet weight, and protein, DNA, and RNA concentrations

	Experimental Group
	Con	HS + T3	7d RL	7d RL + CsA	14d RL	14d RL + CsA
Body wt, g	208±4.6	152±5.1*	195±3.4*†	191±2.7*†	215±3.6†‡§	212±3.6†‡§
Soleus wet wt/body wt, mg/g	0.43±0.01	0.32±0.02*	0.37±0.02*	0.32±0.02*	0.41±0.01†§	0.36±0.01*
Total protein concn, mg/g	206±4	220±7	183±6†	196±8	216±10‡	212±11
Total protein content per muscle, mg/muscle	18±0.8	11±0.8*	14±1*†	12±0.9*	19±1†‡§	16±0.9†§
DNA concn, mg/g	1.7±0.047	2.3±0.12*	2.0±0.059*†	2.1±0.078*†	1.8±0.048†	2.1±0.057*†
DNA content per muscle, μg/muscle	148±6	111±6*	159±9†	126±6*‡	157±9†§	158±9†§
RNA concn, μg/mg	1.2±0.075	1.2±0.070	1.9±0.063*†	1.8±0.021*†	1.4±0.066*†‡§	1.4±0.056*†§

Values are means ± SE. Con, control; HS + T₃, hindlimb suspension + triiodothyronine (T₃); 7d RL, HS + T₃ followed by 7 days of muscle reloading; 7d RL + CsA, 7d RL + cyclosporin A (CsA); 14d RL, HS + T₃ followed by 14 days of reloading; 14d RL + CsA, 14d RL + CsA; concn, concentration. Significant differences by 1-way ANOVA with post hoc test:

^*P < 0.05 vs. Con;

^†P < 0.05 vs. HS + T₃;

^‡P < 0.05 vs. 7d RL;

^§P < 0.05 vs. 7d RL + CsA.