Fig. 6.

Endothelial barrier antigen (EBA) immunohistochemistry as a marker of BBB disruption. Periventricular regions are shown. A: controls. Note the extensive endothelial (vascular) network revealed with EBA in this region of the brain. B represents EBA immunoreactivity in HAT-hypoxic rat brain. Note the marked reduction in EBA expression in HAT-hypoxic rats. RT-hypoxic rats also show a reduction in EBA (data not shown) which appears to be greater in the HAT vs. the RT group (see Figs. 7 and 8). Scale bar, 200 μm.