Table 2.
Rimonabant treated | Event | Placebo treated | Event | CER (%) | EER (%) | NNH | |
---|---|---|---|---|---|---|---|
Any adverse event | |||||||
Rimonabant 5 mg | 2883 | 2364 | 1770 | 1434 | 81 | 82 | 102 |
Rimonabant 20 mg | 3393 | 2861 | 2292 | 1829 | 80 | 84 | 22 |
Total | 6276 | 5225 | 4062 | 3263 | 80 | 83 | 34 |
Serious adverse events | |||||||
Rimonabant 5 mg | 2883 | 149 | 1770 | 79 | 4 | 5 | 142 |
Rimonabant 20 mg | 3393 | 207 | 2292 | 123 | 5 | 6 | 136 |
Total | 6276 | 356 | 4062 | 202 | 5 | 6 | 143 |
Discontinuation due to adverse events | |||||||
Rimonabant 5 mg | 2883 | 232 | 1770 | 125 | 7 | 8 | 102 |
Rimonabant 20 mg | 3815 | 501 | 2708 | 206 | 8 | 13 | 18 |
Total | 6698 | 733 | 4478 | 331 | 7 | 11 | 28 |
Discontinuation due to psychiatric adverse events | |||||||
Rimonabant 5 mg | 2883 | 81 | 1770 | 42 | 2 | 3 | 229 |
Rimonabant 20 mg | 3815 | 230 | 2708 | 72 | 3 | 6 | 30 |
Total | 6698 | 311 | 4478 | 114 | 3 | 5 | 48 |
Discontinuation due to neurologic adverse events | |||||||
Rimonabant 5 mg | 2883 | 26 | 1770 | 13 | 1 | 1 | 597 |
Rimonabant 20 mg | 3684 | 78 | 2581 | 25 | 1 | 2 | 87 |
Total | 6567 | 104 | 4351 | 38 | 1 | 2 | 141 |
CER, control event rate; EER, experimental event rate.