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Limbic-cortical dysregulation model. Interconnected regions are grouped into four ‘compartments’ relating to particular cognitive/behavioural functions. Within compartments there may be a segregation between areas (shown in plain and italic text) showing an inverse relationship on different imaging paradigms. These interactions are dysfunctional in depression and modulated by successful treatment. Adapted from Mayberg (1997) and Mayberg et al. (1999).
