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Thiolated oligonucleotide, ss DNA-SH, was bound selectively to silver colloids deposited on APS-treated quartz substrate. Fluorescein-labeled complementary oligonucleotide, ss Fl-DNA, was injected into the solution. The concentration of Fl-labeled DNA was significantly lower than unlabeled DNA tethered on colloids. For the control we used a sample without thiolated ss DNA.
