. Author manuscript; available in PMC: 2009 Oct 19.

Published in final edited form as: Nat Rev Drug Discov. 2007 Nov;6(11):904–916. doi: 10.1038/nrd2423

Table 2.

Genetic variation associated with statin-induced mytotoxicity

Drug	Gene(s)	Form of toxicity	Cases/controls	Refs
Cerivastatin	CYP2C8	Rhabdomyolysis	1	66
	OATP2 OATP1B1 (SLCO1B1)
Pravastatin	OATPC	Myopathy	1	67
	OATP1B3 (SLCO1B3)
Simvastatin	ABCB1 (MDR1)	Myalgia	15/99	⁶⁸
Atorvastatin	CYP3A5	Myalgia	69/68	³⁹
Multiple statins, including cerivastatin	CPT 2	Myopathy	136/116	69
	AMPD
	PYGM
Multiple statins, including rosuvastatin and atorvastatin	COQ2	Myopathy	133/158	70