. Author manuscript; available in PMC: 2009 Oct 19.

Published in final edited form as: Nat Rev Drug Discov. 2007 Nov;6(11):904–916. doi: 10.1038/nrd2423

Table 3.

Associations between polymorphisms and drug-induced torsades de pointes

Drug	Drug category	Gene(s)	Cases/controls	Refs
Sibutramine	Serotonin and noradrenaline re-uptake inhibitor	KCNQ1	1	¹⁴⁴
Terfenadine	H₁-receptor antagonist	HERG	1	¹⁴⁵
Multiple, including sotalol and quinidine	Anti-arrhythmics and non-anti-arrhythmics	KCNQ1	92/67	114
		HERG
		SCN5A
		KCNQ1
Cisapride	Parasympathomimetic para-aminobenzoic acid inhibitor	HERG	32/32	146
Bactrim	Parasympathomimetic para-aminobenzoic acid inhibitor	SCN5A
Sotalol	β-adrenergic antagonist	KCNH2	9/16	147
Amiodarone	Vaughan-Williams class III anti-arrhythmic
Contrast-media containing iodide	Contrast agent