Table 1.
Pharmacokinetic parameters for whole body clearance of arsenic in C57BL/6 wild-type mice and As3mt knockout mice over 96 hours after oral administration of 0.5 mg of arsenic as [73As]-arsenate per kilogram
Strain | Sex | A intercept | B intercept | Distribution half-life (hr) | Elimination half-life (hr) |
---|---|---|---|---|---|
C57BL/6 wild-type | Male | 13.4 | 0.3 | 7.3 | 250.0 |
Female | 10.0 | 0.3 | 4.4 | 90.5 | |
As3mt knockout | Male | 8.0 | 10.2 | 6.1 | 68.6 |
Female | 6.3 | 8.9 | 6.7 | 68.8 |
Data were fitted using the biexponential equation y(t) = Ae-αt + Be-βt