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. Author manuscript; available in PMC: 2010 Oct 19.
Published in final edited form as: Chem Res Toxicol. 2009 Oct 19;22(10):1713–1720. doi: 10.1021/tx900179r

Table 1.

Pharmacokinetic parameters for whole body clearance of arsenic in C57BL/6 wild-type mice and As3mt knockout mice over 96 hours after oral administration of 0.5 mg of arsenic as [73As]-arsenate per kilogram

Strain Sex A intercept B intercept Distribution half-life (hr) Elimination half-life (hr)
C57BL/6 wild-type Male 13.4 0.3 7.3 250.0
Female 10.0 0.3 4.4 90.5
As3mt knockout Male 8.0 10.2 6.1 68.6
Female 6.3 8.9 6.7 68.8

Data were fitted using the biexponential equation y(t) = Ae-αt + Be-βt