Table 2.
Sample, joint, and donor characteristics. Age, macroscopic grades16 (grade 1: normal, intact surface; grade 2: minimal fibrillation; grade 3: overt fibrillation; grade 4: full thickness erosion) of samples from the medial and lateral femoral condyles and overall joint, percentage area of full thickness cartilage erosion of the femoral condyles and joint, presence of osteophytes, body mass index (BMI), and n of human female and male donors of osteochondral cores from the LFC and MFC. Data are reported as mean ± SEM.
| Lateral Femoral Condyle | Medial Femoral Condyle | |||||
|---|---|---|---|---|---|---|
| NLA | DGN | OA | NLA | DGN | OA | |
| Age (yr) | 68±3 | 68±6 | 69±5 | 67±3 | 69±5 | 68±3 |
| Age range (yr) | 50–91 | 52–87 | 52–82 | 50–78 | 52–84 | 59–82 |
| Sample grade | 1 | 3 | 3 | 1 | 3 | 3 |
| Joint grade | 3.0±0.2 | 4±0 | 4±0 | 2.9±0.2 | 3.8±0.2 | 4.0±0.0 |
| Area of erosion, FC (%) | 0±0 | 6±4* | 22±3***, ††† | 0±0 | 6±4* | 21±4***, ††† |
| Area of erosion, Joint (%) | 0.1±0.1 | 15±4*** | 38±7***, ††† | 0±0 | 11±5* | 31±8***, † |
| Presence of osteophytes | 0/13 | 0/6 | 5/6 | 0/11 | 0/6 | 6/7 |
| BMI (kg/m2) | 24±2 | 27±5 | 30±1 | 22±2 | 25±3 | 28±1 |
| Female | 5 | 4 | 5 | 5 | 3 | 5 |
| Male | 7 | 2 | 1 | 6 | 3 | 2 |
| Female + male | 12 | 6 | 6 | 11 | 6 | 7 |
*
p<0.05,
***
p<0.005 versus NLA samples.
†
p<0.05,
†††
p<0.005 versus DGN samples.