Table 1.
List of yeast deletion mutants that are sensitive or resistant to arsenite. All the sensitive and resistant mutants identified are presented in this table. The mutants are ordered from the most to the least sensitive. IC50 values are indicated in mM sodium arsenite.
| Yeast Protein name |
Yeast Function | IC50 | Human SwissProt number |
Human Function | |
|---|---|---|---|---|---|
| YJL179W | PFD1 | Protein with similarity to bovine prefoldin subunit 1 | 0.2444 | O60925 | Prefoldin subunit 1 |
| YLR113W | HOG1 | MAP kinase (MAPK) central to the high-osmolarity signal transduction pathway |
0.3059 | Q16539 | Mitogen-activated protein kinase 14 |
| YJR090C | GRR1 | F-box protein that targets G1 cyclins and Gic1p and other proteins for degradation by the SCF-Grr1p complex (Skp1p-Cdc53p-Cdc34p-Grr1p); also required for glucose repression and for glucose and cation transport |
0.3464 | AAH07557 | F-box/LRR-repeat protein 20 |
| YDR448W | ADA2 | Component of two nucleosomal histone | 0.375 | O75478 | Transcriptional adapter 2-alpha |
| YBR278W | DPB3 | DNA polymerase epsilon third subunit | 0.4023 | Q9NR33 | DNA polymerase epsilon subunit 4 |
| YCR027C | RHB1 | Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins |
0.4121 | Q15382 | GTP-binding protein Rheb [Precursor] |
| YPL105C | SYH1 | Protein of unknown function that may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
0.4152 | O75137 | PERQ amino acid-rich with GYF domain-containing protein 2 |
| YOL081W | IRA2 | GTPase-activating protein for Ras1p and Ras2p | 0.4156 | P21359 | Neurofibromin |
| YGL084C | GUP1 | Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport |
0.4504 | Q9NVH9 | Protein-cysteine N- palmitoyltransferase HHAT |
| YNL229C | URE2 | Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion |
0.4504 | P30711 | Glutathione S-transferase theta-1 |
| YEL003W | GIM4 | Prefoldin subunit 2, component of the Gim protein complex that promotes formation of functional alpha- and gamma-tubulin |
0.4787 | Q9UHV9 | Prefoldin subunit 2 |
| YBR298C | MAL31 | High affinity maltose/H+ symporter (maltose permease), member of the hexose transporter family of the major facilitator superfamily (MFS) |
0.4962 | P11168 | Solute carrier family 2, facilitated glucose transporter member 2 |
| YPL042C | SSN3 | Cyclin-dependent serine/threonine protein kinase of the RNA polymerase II holoenzyme complex and Kornberg's mediator (SRB) subcomplex |
0.4992 | P49336 | Cell division protein kinase 8 |
| YGR252W | GCN5 | Component of two nucleosomal histone acetyltransferase complexes |
0.4996 | Q92831 | Histone acetyltransferase PCAF |
| YJL128C | PBS2 | MAP kinase kinase (MEK) activated by high osmolarity through the Sln1p-Ypd1p-Ssk1p two-component osmosensor and the Sho1p osmosensor |
0.5 | P36507 | Dual specificity mitogen-activated protein kinase kinase 2 |
| YNL307C | MCK1 | Serine/threonine/tyrosine protein kinase, positive regulator of meiosis and spore formation |
0.5 | AAH27984 | Glycogen synthase kinase-3 alpha |
| YBL051C | PIN4 | Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage |
0.5056 | AAN05429 | Cleavage stimulation factor 64 kDa subunit, tau variant |
| YCL001W-A | Protein of unknown function | 0.5102 | |||
| YBR133C | HSL7 | Negative regulatory protein of the Swe1p protein kinase | 0.5163 | Q9UKH1 | Protein arginine N- methyltransferase 5 |
| YCR009C | RVS161 | Protein required for viability after N, C, or S starvation, for internalization step of endocytosis, and for cell fusion during mating; roles in endocytosis and in cell fusion are independent of one another |
0.5181 | Q9NQY0 | Bridging integrator 3 |
| YGL012W | ERG4 | Sterol C-24 (28) reductase | 0.5262 | Q14739 | Lamin-B receptor |
| YCL010C | SGF29 | SaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGA histone acetyltransferase complex |
0.527 | Q96ES7 | SAGA-associated factor 29 homolog |
| YNR031C | SSK2 | Map kinase kinase kinase (MAPKKK) of the high- osmolarity signal transduction pathway |
0.552 | BAA13204 | Mitogen-activated protein kinase kinase kinase 4 |
| YDR028C | REG1 | Regulatory subunit for protein phosphatase Glc7p, required for glucose repression |
0.5533 | Q9NZW4 | Dentin sialophosphoprotein [Precursor] |
| YBL007C | SLA1 | Protein involved in assembly of cortical actin cytoskeleton, has three SH3 domains |
0.5535 | Q9UIQ3 | Proto-oncogene tyrosine-protein kinase FGR |
| YER014C-A | BUD25 | Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild- type bipolar pattern |
0.5587 | ||
| YCR045C | Protein with similarity to protease B (Prb1p) and subtilisin family proteases |
0.5638 | Q8NBP7 | Proprotein convertase subtilisin/kexin type 9 [Precursor] |
|
| YER155C | BEM2 | GTPase-activating (GAP) protein; regulates Rho1p and has a role in bud emergence and cell cycle-related cytoskeletal reorganization |
0.5718 | AAH38976 | Rho GTPase-activating protein 15 |
| YCR026C | NPP1 | Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation |
0.5725 | Q9UJA9 | Ectonucleotide pyrophosphatase/phosphodiesterase e family member 5 [Precursor] |
| YER110C | KAP123 | Karyopherin-beta involved in nuclear import of ribosomal proteins |
0.5772 | Q8TEX9 | Importin-4 |
| YCL063W | VAC17 | Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p |
0.5813 | AAH40354 | Caldesmon |
| YBR286W | APE3 | Aminopeptidase Y (yscIII, APY), major vacuolar aminopeptidase with preference for basic amino acids and proline |
0.582 | Q9UQQ1 | N-acetylated-alpha-linked acidic dipeptidase-like protein |
| YDR359C | EAF1 | Component of the NuA4 histone acetyltransferase complex; required for initiation of pre-meiotic DNA replication, probably due to its requirement for significant expression of IME1 |
0.5904 | Q96L91 | E1A-binding protein p400 |
| YCL032W | STE50 | Protein required for feedback control of pheromone- induced signal transduction |
0.5926 | O43419 | Intestinal mucin [Fragment] |
| YBR281C | DUG2 | Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma- glutamyl transpeptidase (Ecm38p) |
0.599 | Q96KN2 | Beta-Ala-His dipeptidase [Precursor] |
| YCR087C-A | LUG1 | Protein of unknown function | 0.6023 | ||
| YPL165C | SET6 | Protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability |
0.6043 | Q9NRG4 | SET and MYND domain-containing protein 2 |
| YDR388W | RVS167 | Protein that affects actin distribution and bipolar budding, has an SH3 domain |
0.605 | Q96HL8 | SH3 domain-containing YSC84-like protein 1 |
| YER007W | PAC2 | Putative tubulin-specific chaperone, involved in formation of alpha-beta-tubulin heterodimer |
0.6177 | Q15813 | Tubulin-specific chaperone E |
| YCR036W | RBK1 | Ribokinase; member of a family of sugar kinases that includes Pfk2p |
0.6283 | Q9H477 | Ribokinase |
| YML121W | GTR1 | Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB |
0.6322 | AAH34726 | Ras-related GTP-binding protein B |
| YCL037C | SRO9 | Suppressor of ypt6 null and rho3 mutations | 0.6364 | Q9NW12 | La-related protein 2 |
| YLR079W | SIC1 | P40 inhibitor of Cdc28p-Clb protein kinase complex | 0.6452 | Q8NHA9 | Seven transmembrane helix receptor |
| YHR013C | ARD1 | Protein N-acetyltransferase subunit; mating functions are reduced in mutants due to derepression of silent mating type loci |
0.6467 | P41227 | N-terminal acetyltransferase complex ARD1 subunit homolog A |
| YJL136C | RPS21B | Ribosomal protein S21 (yeast S26; YS25; rat S21), to Rps21Ap |
0.6509 | Q8WVC2 | RPS21 protein |
| YAL047C | SPC72 | Component of spindle pole body that interacts with Stu2p |
0.6523 | ||
| YCL033C | Putative protein-methionine-R-oxide reductase; involved in response to oxidative stress; similar to mouse Sepx1p and fly SelRp; YCL033C is not an essential gene |
0.6639 | Q9Y3D2 | Methionine-R-sulfoxide reductase B2, mitochondrial [Precursor] |
|
| YPL059W | GRX5 | Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron- sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p |
0.6678 | AAH23528 | Glutaredoxin-related protein 5 |
| YDR335W | MSN5 | Karyopherin involved in nuclear import and export; to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p, Far1p, and Pho4p; cargo dissociation involves binding to RanGTP |
0.6794 | Q9BZV5 | Exportin-5 |
| YOR290C | SNF2 | Component of SWI-SNF global transcription activator complex, acts to assist gene-specific activators through chromatin remodeling |
0.6797 | Q9HBD4 | SMARCA4 isoform 2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, isoform CRA_c) |
| YPL174C | NIP100 | Mitotic spindle positioning protein, dynactin complex protein associated with the spindle |
0.683 | P30622 | CAP-Gly domain-containing linker protein 1 |
| YKL006W | RPL14A | Ribosomal protein L14 (mammalian L14), nearly identical to Rpl14Bp |
0.6885 | P50914 | 60S ribosomal protein L14 |
| YGR078C | PAC10 | Protein required in the absence of Cin8p | 0.6981 | CAA76761 | Prefoldin subunit 3 |
| YCL060C | Protein of unknown function | 0.7028 | |||
| YBR231C | SWC5 | Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A |
0.7067 | Q9UEE9 | Craniofacial development protein 1 |
| YEL027W | CUP5 | Protein of unknown function | 0.7128 | P27449 | Vacuolar ATP synthase 16 kDa proteolipid subunit |
| YEL031W | SPF1 | Putative Ca2+-transporting ATPases, member of the P- type ATPase superfamily |
0.7154 | Q9HD20 | Probable cation-transporting ATPase 13A1 |
| YPL084W | BRO1 | Protein that interacts with components of the PKC1- MAP kinase pathway |
0.7197 | Q9BX86 | Programmed cell death 6-interacting protein |
| YPL262W | FUM1 | Fumarate hydratase; mitochondrial and cytoplasmic fumarase, converts L-malate to fumarate as part of the cycle |
0.7284 | P07954 | Fumarate hydratase, mitochondrial [Precursor] |
| YOL001W | PHO80 | Cyclin that interacts with Pho85p protein kinase, regulates the phosphate pathway through phosphorylation of Pho4p |
0.7321 | Q9H4N0 | Uncharacterized protein C2orf24 |
| YOR360C | PDE2 | 3',5'-Cyclic-nucleotide phosphodiesterase, high-affinity | 0.7328 | Q13945 | 3',5'-cyclic AMP phosphodiesterase [Fragment] |
| YGL066W | SGF73 | Subunit of SAGA histone acetyltransferase complex; in formation of the preinitiation complex assembly at promoters; null mutant displays defects in premeiotic DNA synthesis |
0.7364 | Q9ULK2 | Ataxin-7-like protein 1 |
| YAR002aW | Protein of unknown function | 0.7652 | |||
| YNL087W | TCB2 | Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud |
0.7657 | Q96LX0 | Multiple C2 and transmembrane domain-containing protein 1 |
| YKL213C | DOA1 | WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase |
0.77 | Q9UF53 | Phospholipase A-2-activating protein |
| YML124C | TUB3 | Tubulin alpha-3 chain, non-essential | 0.7732 | AAH06468 | Tubulin alpha-1A chain |
| YKL119C | VPH2 | Vacuolar H(+)-ATPase (V-ATPase) assembly protein in the endoplasmic reticulum |
0.7901 | O75336 | Liprin-beta-1 |
| YDR393W | SHE9 | Protein with similarity to Arabidopsis thaliana CIP1, lethality when overexpressed |
0.793 | P13533 | Myosin-6 |
| YOL012C | HTA3 | Histone-related protein that can suppress histone H4 point mutation |
0.8078 | AAH20936 | Histone H2A.Z |
| YDR069C | DOA4 | Ubiquitin-specific protease (ubiquitin C-terminal hydrolase), involved in recycling ubiquitin from protein substrates targeted to the proteasome and the vacuole |
0.8121 | P40818 | Ubiquitin carboxyl-terminal hydrolase |
| YBR085W | AAC3 | ADP/ATP transporter protein, member of the mitochondrial carrier (MCF) family |
0.8173 | AAH31912 | ADP/ATP translocase 3 |
| YBL047C | EDE1 | Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins |
0.8291 | Q9UBC2 | Epidermal growth factor receptor substrate 15-like 1 |
| YER151C | UBP3 | Ubiquitin-specific protease, ubiquitin C-terminal hydrolase |
0.834 | Q9BWG7 | Ubiquitin carboxyl-terminal hydrolase 10 |
| YJR073C | OPI3 | Phospholipid-N-methyltransferase; carries out second and third methylation steps of the phosphatidylcholine biosynthesis pathway |
0.8357 | Q9BW86 | Phosphatidylethanolamine N- methyltransferase |
| YCR020C-A | MAK31 | Protein required for structural stability of L-A double- stranded RNA- (dsRNA-) containing particles, has similarity to snRNA-associated proteins of the Sm family |
0.8388 | ||
| YNR010W | CSE2 | Component of RNA polymerase II mediator (SRB) subcomplex |
0.8433 | O75179 | Ankyrin repeat domain-containing protein 17 |
| YBR284W | Putative protein of unknown function | 0.8464 | Q96IA1 | AMP deaminase 2 | |
| YAL012W | CYS3 | Cystathionine gamma-lyase, generates cysteine from cystathionine |
0.8467 | P32929 | Cystathionine gamma-lyase |
| YPR179C | HDA3 | Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p |
0.8494 | Q8N7Z2 | Golgin subfamily A member 6-like protein 1 |
| YNL201C | PSY2 | Putative subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and the regulatory subunit Psy4p; required for cisplatin and oxaliplatin resistance; localizes to nucleus |
0.8569 | BAC23106 | SMEK1 |
| YGR061C | ADE6 | 5'-phosphoribosylformyl glycinamidine synthetase, has glutamine amidotransferase domain and aminator domain |
0.8577 | Q9BX02 | |
| YNL107W | YAF9 | Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain |
0.8635 | O95619 | YEATS domain-containing protein 4 |
| YCL008C | STP22 | Protein required for vacuolar targeting of temperature- sensitive plasma membrane proteins such as Ste2p and Can1p |
0.872 | Q9BUM5 | Tumor susceptibility gene 101 protein |
| YLR025W | SNF7 | Protein involved in glucose derepression and in protein sorting in pre-vacuolar endosome |
0.8731 | Q9H444 | Charged multivesicular body protein 4b |
| YBR200W | BEM1 | Protein required for cell polarization and bud formation, contains two SH3 domains |
0.8796 | Q9Y338 | Sorbin and SH3 domain-containing protein 1 |
| YJL080C | SCP160 | Protein involved in control of mitotic chromosome transmission, contains 14 KH motifs found in RNA- binding proteins such as Mer1p and mouse hnRNP X |
0.8926 | AAH01179 | Vigilin |
| YOR124C | UBP2 | Ubiquitin-specific protease (ubiquitin C-terminal hydrolase), cleaves at the C-terminus of ubiquitin |
0.9048 | Q96RU2 | Ubiquitin carboxyl-terminal hydrolase 28 |
| YDR293C | SSD1 | Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence |
0.9048 | Q9Y2L1 | Exosome complex exonuclease RRP44 |
| YML014W | TRM9 | tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNA(Arg3) and tRNA(Glu), likely as part of a complex with Trm112p; deletion confers resistance to zymocin |
0.9082 | Q9P272 | Putative methyltransferase KIAA1456 |
| YDL101C | DUN1 | Protein kinase required for induction of Rnr3p and DNA repair genes after DNA damage |
0.9116 | O96017 | Serine/threonine-protein kinase Chk2 |
| YDL146W | LDB17 | Protein of unknown function | 0.912 | AAH16052 | NCK interacting protein with SH3 domain |
| YDR358W | GGA1 | Golgi-localized protein with homology to gamma- adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi |
0.9303 | Q9NZ52 | ADP-ribosylation factor-binding protein GGA3 |
| YBR030W | RKM3 | Protein with weak similarity to Sin3p | 0.9322 | Q9H787 | SET domain-containing protein 6 |
| YLL039C | UBI4 | Ubiquitin, mature protein is cleaved from polyubiquitin (Ubi4p) or from fusions with ribosomal proteins Rps31p, Rpl40Ap, or Rpl40Bp |
0.9427 | AAH39193 | Ubiquitin |
| YLR417W | VPS36 | Protein involved in vacuolar sorting; mutant has a prominent novel pre-vacuolar organelle |
0.9471 | Q9H8Z5 | Vacuolar protein-sorting-associated protein 36 |
| YKR007W | MEH1 | Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification |
0.9476 | Q9NVC8 | Ubiquitin carboxyl-terminal hydrolase 36 |
| YBL064C | PRX1 | Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated |
0.9489 | AAH35857 | Peroxiredoxin-6 |
| YLR447C | VMA6 | Vacuolar H(+)-ATPase (V-ATPase) 36 kDa subunit (subunit D) of membrane (V0) sector, required for V- ATPase assembly |
0.9493 | P12953 | Vacuolar proton pump subunit d 1 |
| YOR371C | GPB1 | Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb2p |
0.9591 | P51610 | Host cell factor |
| YKL134C | 10/1/1999 | Mitochondrial intermediate peptidase | 0.9685 | Q96G65 | Mitochondrial intermediate peptidase [Precursor] |
| YDR300C | PRO1 | Glutamate 5-kinase, carries out first step in proline biosynthesis pathway |
0.9723 | P54886 | Delta-1-pyrroline-5-carboxylate synthetase |
| YCR034W | FEN1 | Protein involved in the elongation of fatty acids up to 24 carbons |
0.9727 | Q9NYP7 | Elongation of very long chain fatty acids protein 5 |
| YLR200W | YKE2 | Protein involved in microtubule biogenesis | 1.001 | AAH39033 | Prefoldin subunit 6 |
| YOR322C | LDB19 | Protein of unknown function involved in maintenance of proper telomere length; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface |
1.005 | Q9UJF2 | Ras GTPase-activating protein nGAP |
| YOL039W | RPP2A | Acidic ribosomal protein P2A (L44; A2; YP2alpha; E. coli L12eIB; human P2alpha), plays a role in the elongation step |
1.007 | P05387 | 60S acidic ribosomal protein P2 |
| YPL158C | AIM44 | Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays increased frequency of mitochondrial genome loss and reduced growth rate in minimal glycerol media |
1.009 | Q8NAM5 | Putative protein TPRXL |
| YKL041W | VPS24 | Protein involved in sorting of proteins in pre-vacuolar endosome |
1.012 | Q9Y3E7 | Charged multivesicular body protein 3 |
| YML057W | CMP2 | Calcineurin catalytic (A) subunit, protein serine/threonine phosphatase 2B (PP2B), member of the PPP family of protein phosphatases |
1.022 | Q8TAW9 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform |
| YLR335W | NUP2 | Nuclear pore protein (nucleoporin) with XFXFG motifs; has functional overlap with other proteins of nuclear pore complex |
1.026 | P49792 | E3 SUMO-protein ligase RanBP2 |
| YGR101W | PCP1 | Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases | 1.033 | Q96CQ4 | Presenilins-associated rhomboid-like protein, mitochondrial [Precursor] |
| YNL021W | HDA1 | Component of histone deacetylase A, 75 kDa subunit | 1.043 | Q9NSW6 | Putative uncharacterized protein DKFZp566E044 |
| YOR265W | RBL2 | Protein that rescues excess beta-tubulin lethality | 1.045 | O75347 | Tubulin-specific chaperone A |
| YDL020C | RPN4 | Subunit of the regulatory particle of the proteasome | 1.046 | AAH36038 | Zinc finger protein 25 |
| YHR082C | KSP1 | Serine/threonine kinase that suppresses prp20 mutant when oveproduced |
1.048 | Q9P0L2 | Serine/threonine-protein kinase MARK1 |
| YJL204C | RCY1 | F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth |
1.056 | O00471 | Exocyst complex component 5 |
| YHR026W | PPA1 | Proteolipid of the vacuolar H(+)-ATPase (V-ATPase) | 1.058 | Q99437 | Vacuolar ATP synthase 21 kDa proteolipid subunit |
| YKL212W | SAC1 | Phosphatidylinositol phosphate (PtdInsP) phosphatase involved in hydrolysis of PtdIns[4]P; transmembrane protein localizes to ER and Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance |
1.06 | O94935 | Phosphatidylinositide phosphatase SAC1 |
| YGL240W | DOC1 | Component of the anaphase-promoting complex (APC); required for Clb2p degradation and for the metaphase- anaphase transition |
1.06 | Q9Y5R0 | Anaphase-promoting complex subunit 10 |
| YKR031C | SPO14 | Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis |
1.061 | O14939 | Phospholipase D2 |
| YFL025C | BST1 | GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi- bound cargo molecules |
1.066 | Q9HA24 | GPI inositol-deacylase |
| YDL223C | HBT1 | Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis |
1.066 | Q9NZW4 | Dentin sialophosphoprotein, [Precursor] |
| YNL298W | CLA4 | Serine/threonine protein kinase required for cytokinesis | 1.068 | Q13153 | Serine/threonine-protein kinase PAK |
| YPL002C | SNF8 | Protein involved in glucose derepression | 1.076 | Q96H20 | Vacuolar-sorting protein SNF8 |
| YNL215W | IES2 | Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; essential for growth under anaerobic conditions |
1.076 | Q16081 | Nexilin |
| YMR004W | MVP1 | Protein required for sorting proteins to the vacuole, interacts genetically with Vps1p |
1.083 | Q9Y5X2 | Sorting nexin-8 |
| YKR100C | SKG1 | Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell |
1.085 | Q9NW40 | Pre-mRNA-splicing factor 38B |
| YJL189W | RPL39 | Ribosomal protein L39 | 1.09 | P02404 | 60S ribosomal protein L39 |
| YAR015W | ADE1 | Phosphoribosylamidoimidazole-succinocarboxamide synthase; (SAICAR synthetase), catalyzes the seventh step in de novo purine biosynthesis pathway |
1.097 | P22234 | Multifunctional protein ADE2 |
| YNL097C | PHO23 | Protein involved in expression of PHO5 | 1.1 | Q9NXR8 | Inhibitor of growth protein 3 |
| YAL002W | VPS8 | Protein involved in vacuolar sorting | 1.102 | Q8N3P4 | Vacuolar protein sorting-associated protein 8 homolog |
| YML058C-A | Protein of unknown function | 1.11 | |||
| YJL047C | RTT101 | Protein of the cullin family, with similarity to Cdc53p | 1.11 | AAH09591 | Cullin-2 ( |
| YJR145C | RPS4A | Ribosomal protein S4 (yeast S7; YS6; rp5; rat and human S4), identical to Rps4Bp |
1.11 | P12750 | 40S ribosomal protein S4, X isoform |
| YPR030W | CSR2 | Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate |
1.111 | Q9NZW4 | Dentin sialophosphoprotein [Precursor] |
| YNR051C | BRE5 | Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A |
1.121 | Q9BX49 | Proteoglycan-4 [Precursor] |
| YGR180C | RNR4 | Ribonucleotide reductase small subunit | 1.123 | AAH30154 | Ribonucleoside-diphosphate reductase subunit M2 |
| YKL135C | APL2 | Beta-adaptin, large subunit of the clathrin-associated protein (AP) complex |
1.123 | Q96J19 | AP-2 complex subunit beta-1 |
| YJL036W | SNX4 | Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p |
1.124 | O95219 | Sorting nexin-4 |
| YOL072W | THP1 | Nuclear pore-associated protein, forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus; contains a PAM domain implicated in protein-protein binding |
1.133 | Q9NWH3 | PCI domain-containing protein 2 |
| YDL155W | CLB3 | G2/M-phase-specific cyclin | 1.137 | O95067 | G2/mitotic-specific cyclin-B2 |
| YJR075W | HOC1 | Subunit of the Anp1p-Hoc1p-Mnn11p-Mnn9p mannosyltransferase complex of the Golgi involved in cell wall integrity |
1.14 | Q9Y6P7 | snRNA-activating protein complex subunit 4 |
| YOR201C | PET56 | Ribose methyltransferase specific for G2270 in mitochondrial 21S rRNA |
1.145 | Q13395 | Probable methyltransferase TARBP1 |
| YKL143W | LTV1 | Protein required for viability at low temperature | 1.148 | Q96GA3 | Protein LTV1 homolog |
| YJL062W | LAS21 | Protein required for addition of a side chain to the glycosylphospatidylinositol (GPI) core structure |
1.151 | Q8NCC9 | GPI ethanolamine phosphate transferase 2 |
| YJR113C | RSM7 | Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein |
1.152 | P46782 | 40S ribosomal protein S5 |
| YBR295W | PCA1 | P-type copper-transporting ATPase | 1.166 | P35670 | Copper-transporting ATPase 2 |
| YKL197C | PEX1 | AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis |
1.176 | AAH35575 | Peroxisome biogenesis factor 1 |
| YDR099W | BMH2 | Homolog of mammalian 14-3-3 protein, has strong similarity to Bmh1p |
1.178 | AAH39025 | |
| YPL032C | SVL3 | Protein involved in vacuolar uptake of endocytosed vital dyes |
1.186 | Q8NAM5 | Putative protein TPRXL |
| YGR270W | YTA7 | Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p |
1.196 | Q8N890 | ATPase family AAA domain- containing protein 2 |
| YDL081C | RPP1A | Acidic ribosomal protein P1A (A1; YP1alpha; E. coli L12eIIA; human and rat P1) |
1.208 | P05386 | 60S acidic ribosomal protein P1 |
| YLR268W | SEC22 | Synaptobrevin (v-SNARE) homolog involved in fusion of ER-to-Golgi transport vesicles; recognized by putative target t-SNARE (Sed5p) |
1.209 | O75396 | Vesicle-trafficking protein SEC22b |
| YPR051W | MAK3 | Protein N-acetyltransferase, acetylates N-terminus of L- A virus GAG protein |
1.212 | P41227 | N-terminal acetyltransferase complex ARD1 subunit homolog A |
| YGL167C | PMR1 | Ca2+-transporting P-type ATPase of Golgi membrane involved in Ca2+ import into Golgi |
1.212 | P98194 | Calcium-transporting ATPase type 2C member 1 |
| YNR006W | VPS27 | Protein involved in vacuolar sorting; mutants develop a prominent novel pre-vacuolar organelle |
1.213 | Q9NR36 | Hepatocyte growth factor-regulated tyrosine kinase substrate |
| YKL009W | MRT4 | Protein involved in mRNA turnover | 1.214 | Q9UKD2 | mRNA turnover protein 4 homolog |
| YPL079W | RPL21B | Ribosomal protein L21 (rat L21), nearly identical to Rpl21Ap |
1.229 | P46778 | 60S ribosomal protein L21 |
| YJR102C | VPS25 | Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome |
1.235 | Q9BRG1 | Vacuolar protein-sorting-associated protein 25 |
| YOR332W | VMA4 | Vacuolar H(+)-ATPase (V-ATPase) hydrophilic subunit (subunit E), 27 kDa subunit of V1 sector |
1.237 | AAH04443 | Vacuolar proton pump subunit E 1 |
| YNR071C | Putative protein of unknown function | 1.238 | Q96C23 | Aldose 1-epimerase | |
| YPL247C | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest |
1.242 | O15491 | WD repeat-containing protein 68 | |
| YMR052C-A | Protein of unknown function | 1.242 | |||
| YNL091W | NST1 | Protein with similarity to Uso1p and human NF2 neurofibromatosis type 2 gene product |
1.258 | Q8NAM5 | Putative protein TPRXL |
| YKL067W | YNK1 | Nucleoside diphosphate kinase, responsible for synthesis of all nucleoside triphosphates except ATP |
1.268 | P22392 | Nucleoside diphosphate kinase B |
| YBR111C | YSA1 | Nucleoside diphosphate-sugar hydrolase of the MutT (nudix) family |
1.27 | Q9UKK9 | ADP-sugar pyrophosphatase |
| YOR089C | VPS21 | GTP-binding protein of the rab family required for sorting of vacuolar proteins and involved in late stage of endocytosis |
1.272 | AAO15677 | RAB5A protein |
| YEL012W | UBC8 | Ubiquitin-conjugating enzyme that is able to ubiquitinate histones in vitro |
1.276 | P37286 | Ubiquitin-conjugating enzyme E2 H |
| YBL090W | MRP21 | Mitochondrial ribosomal protein of the small subunit | 1.282 | P82921 | 28S ribosomal protein S21, mitochondrial |
| YGL256W | ADH4 | Alcohol dehydrogenase IV | 1.283 | AAK44223 | Hydroxyacid-oxoacid transhydrogenase, mitochondrial precursor |
| YEL062W | NPR2 | Nitrogen permease regulator | 1.295 | Q9Y249 | Tumor suppressor candidate 4 |
| YJL112W | MDV1 | Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats |
1.299 | Q96LE0 | F-box/WD repeat-containing protein 7 |
| YOR295W | UAF30 | Subunit of UAF (upstream activation factor), which is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate |
1.3 | Q96GM5 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 |
| YML081C-A | ATP18 | Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms |
1.31 | ||
| YML032C | RAD52 | Protein required for recombination and repair of X-ray damage, has a late function in meiotic recombination |
1.31 | P43351 | DNA repair protein RAD52 homolog |
| YMR116C | ASC1 | Abundant protein with effects on translational efficiency and cell size, has two WD (WD-40) repeats |
1.311 | AAH32006 | Guanine nucleotide-binding protein subunit beta-2-like 1 |
| YJR104C | SOD1 | Copper-zinc superoxide dismutase | 1.316 | AAL15444 | Superoxide dismutase |
| YJL121C | RPE1 | Ribulose-5-phosphate 3-epimerase, interconverts ribulose-5-phosphate and xylulose-5-phosphate |
1.317 | Q9BSB5 | Ribulose-phosphate 3-epimerase |
| YLR148W | PEP3 | Vacuolar peripheral membrane protein involved in vacuolar protein sorting and required for vacuole biogenesis |
1.317 | Q9P253 | Vacuolar protein sorting-associated protein 18 homolog |
| YOR258W | HNT3 | Member of the third branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins; similar to Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia |
1.322 | Q9NXM5 | |
| YMR198W | CIK1 | Coiled-coil protein of spindle pole body involved in spindle formation and the congression (nuclear migration) step of karyogamy |
1.322 | Q13439 | Golgin subfamily A member 4 |
| YKR020W | VPS51 | Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p |
1.324 | Q13999 | Kinectin |
| YJL102W | MEF2 | Mitochondrial translation elongation factor, promotes GTP-dependent translocation of nascent chain from A- site to P-site of ribosome |
1.33 | Q8N6D8 | G elongation factor, mitochondrial 2 |
| YJL063C | MRPL8 | Mitochondrial ribosomal protein of the large subunit (YmL8) |
1.338 | Q9C066 | 39S ribosomal protein L17, mitochondrial [Precursor] |
| YIL148W | RPL40A | Fusion protein comprised of ribosomal protein L40 (C- terminal half) and ubiquitin (N-terminal half) (rat L40), identical to Rpl40Bp |
1.338 | Q9BX98 | 60S ribosomal protein L40 |
| YPL045W | VPS16 | Vacuolar sorting protein; mutant has pleiotropic defects in vacuolar morphology and vacuolar protein targeting |
1.342 | Q9H269 | Vacuolar protein sorting-associated protein 16 homolog |
| YKL160W | ELF1 | Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression |
1.343 | Q96II4 | Transcription elongation factor 1 homolog |
| YPR024W | YME1 | Mitochondrial zinc-dependent protease of the AAA family of ATPases |
1.357 | AAH23507 | ATP-dependent metalloprotease YME1L1 |
| YGL136C | MRM2 | Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ |
1.357 | Q9UI43 | Putative ribosomal RNA methyltransferase 2 |
| YKR055W | RHO4 | Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity |
1.36 | P06749 | Transforming protein RhoA precursor |
| YGR092W | DBF2 | Serine/threonine protein kinase related to Dbf20p, required for events in anaphase/telophase |
1.36 | Q9Y2H1 | Serine/threonine-protein kinase 38- like |
| YNL022C | Protein of unknown function | 1.377 | Q9NW70 | Putative methyltransferase NSUN5 | |
| YMR145C | NDE1 | Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain |
1.378 | AAH23601 | Apoptosis-inducing factor 2 |
| YKL211C | TRP3 | Bifunctional enzyme exhibiting both indole-3-glycerol- phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p |
1.379 | AAH12178 | GMP synthase |
| YML016C | PPZ1 | Protein serine/threonine phosphatase required for normal osmoregulation, member of the PPP family of protein phosphatases and related to PP1 phosphatases |
1.383 | P36873 | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit |
| YKR099W | BAS1 | Transcription factor; involved in regulation of basal and induced activity of histidine and adenine biosynthesis genes |
1.388 | Q9Y6P7 | snRNA-activating protein complex subunit 4 |
| YAL043C-A | Protein of unknown function | 1.395 | |||
| YDL065C | PEX19 | Farnesylated protein required for peroxisome biogenesis (peroxin) |
1.395 | Q9HAT7 | Ninein |
| YOR027W | STI1 | Stress-induced protein required for optimal growth at high and low temperature, has tetratricopeptide (TPR) repeats |
1.397 | P31948 | Stress-induced-phosphoprotein 1 |
| YPL254W | HFI1 | Component of the ADA complex, interacts functionally with histone H2Ai |
1.398 | Q96FJ7 | Protein ADRM1 |
| YAL042W | ERV46 | Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport |
1.403 | Q9Y282 | Endoplasmic reticulum-Golgi intermediate compartment protein 3 |
| YOR359W | VTS1 | Post-transcriptional gene regulator, RNA-binding protein containing a SAM domain; shows genetic interactions with Vti1p, which is a v-SNARE involved in cis-Golgi membrane traffic |
1.406 | Q9UPU9 | Sterile alpha motif domain- containing protein 4A |
| YLR119W | SRN2 | Suppressor of rna1-1 mutant | 1.407 | Q96KQ3 | Apoptosis-stimulating of p53 protein 2 |
| YML026C | RPS18B | Ribosomal protein S18 (E. coli S13; rat S18), identical to Rps18Ap |
1.413 | P25232 | 40S ribosomal protein S18 |
| YFL001W | DEG1 | Pseudouridine synthase that catalyzes the formation of pseudouridine-38 and -39 in cytoplasmic and mitochondrial tRNAs |
1.415 | Q96NB4 | tRNA pseudouridine synthase 3 |
| YOR123C | LEO1 | Protein of unknown function, extremely hydrophilic | 1.42 | Q8WVC0 | RNA polymerase-associated protein LEO1 |
| YKL197C | PEX1 | Peroxisomal biogenesis protein (peroxin); member of the AAA family of ATPases |
1.424 | AAH35575 | Peroxisome biogenesis factor 1 |
| YML033W | Protein of unknown function | 1.424 | |||
| YNL299W | TRF5 | Protein functionally similar to DNA topoisomerase I | 1.424 | Q9Y6C1 | DNA polymerase sigma |
| YGL227W | VID30 | Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); binds FBPase; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm |
1.44 | Q9P264 | Ran-binding protein 10 |
| YLR068W | FYV7 | Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin |
1.453 | Q05682 | Caldesmon |
| YMR039C | SUB1 | Transcriptional coactivator; may be involved in the release of TFIIB from the transcription complex during RNA polymerase II transcription initiation |
1.464 | Q96L29 | Activated RNA polymerase II transcriptional coactivator p15 |
| YMR234W | RNH1 | Ribonuclease H, endonuclease that degrades RNA in RNA-DNA hybrids |
1.47 | O60930 | Ribonuclease H1 |
| YOL051W | GAL11 | Component of RNA polymerase II holoenzyme and Kornberg's mediator complex with positive and negative effects on transcription of individual genes |
1.479 | Q8NAM5 | Putative protein TPRXL |
| YDR017C | KCS1 | Potential transcription factor of the basic leucine zipper (bZIP) type, suppressor of temperature-sensitive growth and hyperrecombination in pkc1-4 |
1.482 | Q96PC2 | Inositol hexaphosphate kinase 3 |
| YNR052C | POP2 | Component of the CCR4 complex required for glucose derepression |
1.482 | AAH17366 | CCR4-NOT transcription complex subunit 8 |
| YMR060C | TOM37 | Component of mitochondrial outer membrane receptor complex, needed only at high temperature, has tetratricopeptide (TPR) repeats |
1.494 | Q13505 | Metaxin-1 |
| YDR001C | NTH1 | Neutral trehalase | 1.494 | O43280 | Trehalase [Precursor] |
| YNL329C | PEX6 | Peroxisomal biogenesis protein (peroxin) of the AAA family of ATPases |
1.497 | Q8WYQ2 | Peroxisome assembly factor 2 |
| YJL172W | CPS1 | Gly-X carboxypeptidase yscS, involved in nitrogen metabolism |
1.507 | Q96DM4 | Probable carboxypeptidase PM20D1 [Precursor] |
| YHR004C | NEM1 | Protein required for nuclear morphology | 1.51 | Q96GQ9 | Serine/threonine-protein phosphatase dullard |
| YJL029C | VPS53 | Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting |
1.554 | Q9BY02 | Vacuolar protein sorting-associated protein 53 homolog |
| YMR219W | ESC1 | Protein of unknown function | 1.586 | Q9NZW4 | Dentin sialophosphoprotein [Precursor] |
| YDR162C | NBP2 | Nap1p-binding protein, has an SH3 domain | 1.612 | Q9P234 | Putative E3 ubiquitin-protein ligase SH3RF1 |
| YGR135W | PRE9 | Proteasome subunit alpha3_sc | 1.619 | Q8TBD1 | Proteasome subunit alpha type-4 |
| YNR032W | PPG1 | Protein serine/threonine phosphatase involved in glycogen accumulation, member of the PPP family of protein phosphatases and related to PP2A phosphatases |
1.718 | P33172 | Serine/threonine-protein phosphatase 4 catalytic subunit |
| YHR066W | SSF1 | Protein with a potential role in mating | 1.731 | ||
| YGR085C | RPL11B | Ribosomal protein L11 (yeast L16; YL22; rp39B; E. coli L5; rat L11), nearly identical to Rpl11Ap |
1.736 | Q9Y674 | 60S ribosomal protein L11 |
| YNL248C | RPA49 | RNA polymerase I third largest subunit | 1.753 | Q96L20 | DNA-directed RNA polymerase I subunit RPA49 |
| YNL302C | RPS19B | Ribosomal protein S19 (rp55; YS16B; rat S19), nearly identical to Rps19Ap |
1.757 | Q8WVX7 | Ribosomal protein S19 [Fragment] |
| YGL228W | SHE10 | Protein that causes lethality when overexpressed | 1.808 | O60437 | Periplakin |
| YDL096C | OPI6 | Protein of unknown function | 1.921 | ||
| YLR061W | RPL22A | Ribosomal protein L22, similar to Rpl22Bp | 1.932 | P35268 | 60S ribosomal protein L22 |
| YDR227W | SIR4 | Coiled-coil protein involved in maintenance of silencing of HMR, HML, and telomeres |
1.936 | BAA74868 | Neurofilament heavy polypeptide |
| YHR178W | STB5 | Protein with similarity to transcription factors | 1.996 | Q8NAM5 | Putative protein TPRXL |
| YKL191W | DPH2 | Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p |
2 | Q9BQC3 | Diphthamide biosynthesis protein 2 |
| YLR388W | RPS29A | Ribosomal protein S29 (yeast S36; YS29; rat S29), similar to Rps29Bp |
2.098 | AAH35313 | 40S ribosomal protein S29 |
| YGL203C | KEX1 | Carboxypeptidase specific for terminal arg or lys, involved in processing precursors of alpha-factor and K1 and K2 killer toxins |
2.115 | Q9BR08 | Lysosomal protective protein [Precursor] |
| YCR031C | RPS14A | Ribosomal protein S14A (rp59, E. coli S11, rat and human S14) involved in crytopleurine resistance, nearly identical to Rps14Bp |
2.199 | P06366 | 40S ribosomal protein S14 |
| YKL190W | CNB1 | Calcineurin regulatory (B) subunit | 2.274 | AAH27913 | Calcineurin subunit B type 1 |
| YNL246W | VPS75 | NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair |
2.5 | Q9UJ03 | |
| YLR024C | UBR2 | Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p- Ubr2p-Rad6p complex |
2.5 | AAL32101 | E3 ubiquitin-protein ligase UBR2 |
| YMR304W | UBP15 | Putative ubiquitin-specific protease, ubiquitin C-terminal hydrolase |
2.5 | Q93009 | Ubiquitin carboxyl-terminal hydrolase 7 |
| YAL023C | PMT2 | Mannosyltransferase; (dolichyl phosphate-D-mannose | 2.932 | Q9P1W0 | Protein O-mannosyl-transferase 2 |
| YML106W | URA5 | Orotate phosphoribosyltransferase 1; fifth step in pyrimidine biosynthesis pathway |
3.233 | BAB93468 | Uridine 5'-monophosphate synthase |
| YOL008W | COQ10 | Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes |
3.487 | Q9BUP4 | Protein COQ10 A, mitochondrial [Precursor] |
| YOR039W | CKB2 | Casein kinase II Protein kinase CK2), regulatory (beta- prime) subunit |
3.597 | AAH35349 | |
| YOR084W | LPX1 | Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self- interaction |
3.599 | Q9NVT5 | Protein phosphatase methylesterase 1 |
| YMR214W | SCJ1 | Homolog of E. coli DnaJ, functions in the endoplasmic reticulum by interaction with Kar2p |
3.943 | O60884 | DnaJ homolog subfamily A member 2 |
| YMR100W | MUB1 | Zinc finger protein, involved in the regulation of bud site selection |
4.642 | CAC16691 | Zinc finger MYND domain- containing protein 19 |
| YKR042W | UTH1 | Mitochondrial outer membrane and cell wall localized SUN family member required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, mitochondrial biogenesis, and cell death |
above 5 | BAB79693 | Receptor activator of nuclear factor kappa B ligand 3 |
| YLL043W | FPS1 | Glycerol channel protein, member of the major intrinsic protein (MIP) family of transmembrane channel proteins |
above 5 | O43315 | Aquaporin-9 |
| YGR072W | UPF3 | Protein involved with Nam7p and Nmd2p in decay of mRNA containing nonsense codons |
above 5 | Q9H1J0 | Regulator of nonsense transcripts 3B |
| YGR097W | ASK10 | Potential transcription factor involved in Skn7p-mediated two-component regulatory system |
above 5 | O75404 | Pre-mRNA-processing factor 40 homolog A |